重组人脑利钠肽治疗老年急性左心功能衰竭的临床疗效及其对血浆醛固酮、内皮素-1的影响  

Effects of recombinant human brain natriuretic peptide on aldosterone and endothelin-1 in treatment of eldly acute heart failure

作　　者：董根山[1] 赵士超[1] 

机构地区：[1]河南省人民医院,郑州450003

出　　处：《山东医药》2010年第21期18-20,共3页Shandong Medical Journal

基　　金：河南省医学科技创新人才工程资助项目(20030069)

摘　　要：目的探讨重组人脑利钠肽(rhBNP)治疗急性左心功能衰竭(AHF)患者的临床疗效及其对血浆醛固酮(ALD)及内皮素-1(ET-1)的影响。方法将52例AHF患者随机均分为两组,对照组用常规治疗加硝酸甘油静滴,治疗组用常规治疗加rhBNP静注,比较两组临床疗效;并用超声心动图检测其心功能指标,检测血浆ALD及ET-1。结果与对照组比,治疗组临床疗效、心功能指标均明显改善,血浆ALD及ET-1明显下降(P均<0.05)。结论 rhBNP是拮抗神经体液因子过度激活的药物,可改善AHF患者的心功能指标,降低其血浆ALD及ET-1。Objective To study the effects of recombinant human brain natriuretic peptide（rhBNP） on eldly patients with acute heart failure（AHF） and the influence on aldosterone and endothelin-1 in blood.Methods A total of 52 patients with acute heart failure was randomly divided into rhBNP group and control group.The rhBNP group received conventional therapy and rhBNP by intravenous injection.The control group received conventional therapy and trinitroglycerol,and their clinical effect was compared.Heart function parameters were detected by ultrasound cardiography.Compared with control group,Aldosterone（ALD） and endothelin-I（ET-1） in blood plasma were detected.Results Compared with control group,clinical effect and heart function parameters were improved,ALD and ET-1 were obviously decreased（all P0.05）.Conclusion rhBNP is a medicine for resisting the excessively activated neurohumour factors,may improve the heart function parameters,and decrease the blood plasma ALD and ET-1 in AHF patients.

关 键 词：重组人脑利钠肽 心力衰竭 急性 醛固酮 内皮素-1 

分 类 号：R541[医药卫生—心血管疾病]