5-苄基-4-叔丁基-2-苄亚氨基噻唑的合成与杀菌活性  

Synthesis and Fungicidal Activities of 4-Tert-butyl-5-benzyl-2-benzyliminothiazoles

作　　者：杨林涛[1] 覃智[1] 陈平[2] 胡艾希[1] 

机构地区：[1]湖南大学化学化工学院,长沙410082 [2]长沙理工大学化学与生物工程学院

出　　处：《应用化学》2010年第6期664-668,共5页Chinese Journal of Applied Chemistry

基　　金：中央高校基本科研业务费专项资金(531107040010)资助项目

摘　　要：5-苄基-4-叔丁基-2-氨基噻唑与水杨醛衍生物反应制备了12种5-苄基-4-叔丁基-2-苄亚氨基噻唑类新化合物。初步测试了25种5-苄基-4-叔丁基-2-苄亚氨基噻唑的杀菌活性。结果表明,化合物1a(500mg/L)对水稻纹枯病菌抑制率为95%;化合物1i、1j、1l、1p、1q和1s(25mg/L)对小麦赤霉病菌的抑制率分别为55.1%、55.1%、51.3%、51.5%、51.5%和51.5%;化合物1i、1l和1s(25mg/L)对辣椒疫霉病菌抑制率分别为51.1%、51.9%和64.9%;化合物1h和1j(25mg/L)对黄瓜灰霉病菌抑制率为53.1%和61.2%;化合物1t、1o和1r(25mg/L)对油菜菌核病菌的抑制率分别为56.1%、56.1%和65.4%;化合物1w(25mg/L)对烟草赤星病菌的抑制率为52.6%。Twelve new 5-benzyl-4-tert-butyl-2-benzyliminothiazoles were synthesized via the reacitions of 5-benzyl-4-tert-butylthiazol-2-amines with salicyladehyde derivatives.The bioassay of twenty five 4-tert-butyl-5-benzyl-2-benzyliminothiazoles were made.The results of preliminary bioassay show that the inhibition rate of compound 1a（500 mg/L） is 95% against R.solani;the inhibition rates of compounds 1i,1j,1l,1p,1q and 1s（25 mg/L） are 55.1%,55.1%,51.3%,51.5%,51.5% and 51.5% against G.zeae respectively;the inhibition rates of compounds 1i,1l and 1s are 51.1%,51.9% and 64.9% against P.capsici;the inhibition rates of compounds 1h and 1j（25 mg/L） are 53.1% and 61.2% against B.cinerea respectively;the inhibition rates of compounds 1t,1o and 1r（25 mg/L） are 56.1%,56.1% and 65.4% against S.sclerotiorum respectively;and the inhibition rate of compound 1w（25 mg/L） is 52.6% against A.alternata.

关 键 词：苄基叔丁基苄亚氨基噻唑 合成 杀菌活性 

分 类 号：O626[理学—有机化学]