氟代芳香族化合物四甲基氟化铵氟代脱硝法的合成  

Synthesis of Fluoroaromatics via Fluorodenitrations with Tetramethylammonium Fluoride

作　　者：胡玉锋[1] 罗军[1] 吕春绪[1] 

机构地区：[1]南京理工大学化工学院,南京210094

出　　处：《应用化学》2010年第6期669-672,共4页Chinese Journal of Applied Chemistry

摘　　要：以高活性无水四甲基氟化铵(TMAFanh.)为氟化试剂,优化反应的条件为:n(Substrate)∶n(TMAFanh.)=1∶1.4、DMF用量为0.4L/mol Substrate,由硝基芳烃化合物经低温氟代脱硝反应合成了含氟芳香族化合物,反应温度80～100℃,反应时间1～5h,氟代产物收率19.4%～99.0%。反应具有原料易得、工艺简单、条件温和、产物收率高和副反应少等优点。An efficient method for the synthesis of fluoroaromatics with tetramethylammonium fluoride（TMAFanh.） as fluorination agent via the fluorodenitration reaction was reported.Fluoroaromatics were obtained from TMAFanh.and nitroaromatics by simply stirring them together at 80-100 ℃ for 1-5 h in an anhydrous solution of DMF in 19.4%-99.0% yields.The nucleophilic fluorinating method has the advantages of mild reaction conditions,high yields,easy work-up and no phenol or ether side-products were detected in the reaction.

关 键 词：TMAFanh. 硝基芳烃 含氟芳香族化合物 氟代脱硝 

分 类 号：O625[理学—有机化学]