特发性血小板减少性紫癜患者幽门螺杆菌尿素酶B检测及抗幽门螺杆菌治疗效果分析  

Measurement of Helicobacter pylori Urease B in Patients with ITP and Effect of Helicobacter pylori Eradication

作　　者：赵静[1] 王兆钺[1] 白艳艳[1] 曹丽娟[1] 

机构地区：[1]苏州大学附属第一医院江苏省血液研究所卫生部血栓与止血重点实验室,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2010年第2期343-346,共4页Suzhou University Journal of Medical Science

基　　金：国家自然科学基金资助项目(30770917);卫生部血栓与止血重点实验开放课题(KLTH-2009-06);江苏省卫生厅135工程开放课题(K0607);苏州市应用基础研究课题(YJS0902)

摘　　要：目的分析特发性血小板减少性紫癜(ITP)患者的幽门螺杆菌(Hp)感染情况,探讨抗Hp治疗对Hp感染阳性ITP患者的疗效。方法 ITP组45例,正常对照组32例,利用双抗夹心ELISA法检测两组Hp感染情况,对Hp感染阳性的ITP患者在治疗ITP的同时加用抗Hp治疗,与ITP组中Hp阴性病例治疗后的血小板数进行比较。结果 ITP组及正常对照组的Hp检出阳性率分别为66.7%与43.8%,ITP组Hp阳性率明显较高(P<0.05);25例Hp阳性的ITP患者经抗Hp治疗后,转阴21例的血小板数明显高于ITP组中Hp阴性组(P<0.05);Hp根除后的21例中,有12例血小板计数明显上升或恢复正常。结论 ITP患者Hp感染阳性率高于正常人;抗Hp治疗可以提高Hp感染的部分ITP患者血小板数量;Hp感染可能与ITP发病有关。Objective To investigate the role of Helicobacter pylori （Hp） infection in patients with idiopathic thrombocytopenic purpura （ITP）,and to explore the therapeutic effect of Hp eradication.Methods ELISA for Hp urease B （ureB） was performed in 45 patients with ITP as well as in 32 normal individuals as that in the controls.Hp-positive ITP patients were treated with Hp eradication procedure,and their platelet counts were compared with those in the Hp-negative patients after treatment.Results The Hp-positive infection rates in the ITP group and control group were 66.7% and 43.8%,respectively （P 0.05）.In 25 patients who received Hp eradication treatment,21 became Hp-negative,and their platelet counts were significantly increased in comparison with those in the Hp-negative ITP patients.Conclusion The frequency of Hp infection in ITP patients is higher than that in normal individuals.Part of chronic ITP patients whose Hp infection is successfully eradicated shows increase in platelet counts.These results suggest that Hp infection play an important role in ITP pathogenesis.

关 键 词：幽门螺杆菌 特发性血小板减少性紫癜 治疗 

分 类 号：R554.6[医药卫生—血液循环系统疾病]