桂枝汤有效部位A对体温双向调节作用机理研究——对下丘脑和隔区AVP及下丘脑NT含量的影响  

Effect and Mechanism of Active Fraction A from Guizhi Decoction on Dual Directional Thermoregulation——Effect on AVP in Hypothalamus and Ventral Septal Area and NT in Hypothalamus in Rats

作　　者：霍海如[1] 谭余庆[1] 李晓芹[1] 郭淑英[1] 周爱香 田甲丽[1] 孙玉茹[1] 贺玉琢[1] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中国实验方剂学杂志》1999年第1期33-36,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金

摘　　要：在酵母诱导的发热大鼠中，桂枝汤有效部位Ａ（Ｆｒ．Ａ）能降低隔区ＡＶＰ和下丘脑ＮＴ含量，对下丘脑ＡＶＰ含量无影响；在安痛定诱导的低体温大鼠中，Ｆｒ．Ａ能提升下丘脑、隔区ＡＶＰ含量和下丘脑ＮＴ含量。结果提示，Ｆｒ．Ａ对发热动物的解热作用与影响下丘脑ＮＴ和隔区ＡＶＰ的释放有关；抑制中枢ＡＶＰ和ＮＴ的释放或利用参予Ｆｒ．Active fraction A(Fr.A),isolated from Guizhi decoction,might lower febrifacient temperature induced by y east in febrile rat with decreasing contents of arginine vasopressin (AVP) in ventral septal area(VSA) and neurotensin(NT) in hypothalamus.Fr.A did not influence the content of AVP in hypothalamus.In aminopyrine induced hypothermal rats,Fr.A could raise body temperature and contents of AVP in both hypothalamus and VSA and NT in hypothalamus.The results indicated that febrifugal effect of Fr.A was related with its promoting release of AVP in VSA and NT in hypothalamus,while its inhibiting release and/or action of AVP and NT in the thermoregulatory center was involved in mechanism of Fr. A ragulating hypothermia.

关 键 词：桂枝汤 体温调节 精氨酸加压素 神经降压素 

分 类 号：R285.5[医药卫生—中药学] R289.5[医药卫生—中医学]