异常胰胆管连接与胆囊上皮细胞增殖活性的关系研究  

The Experimental Studies of the Relationships between the X ray Findings of APBDU and the Activities of Gallbladder Epithelia

作　　者：秦伟[1] 巫北海[1] 唐成 丁远仁 陈兆珍 

机构地区：[1]重庆第三军医大学西南医院放射科

出　　处：《中国医学影像技术》1999年第2期132-134,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨ＡＰＢＤＵＸ线表现与胆囊上皮细胞增殖活性的关系。方法１９只犬随机分为Ｐ、Ｂ和Ｃ组，术后按期行胆囊活检及胆胰管Ｘ线造影，并对活检标本行病理学检查及ＤＮＡ含量、ＡｇＮＯＲｓ和蛋白质总量测定。结果①Ｂ组７只中６只胆管扩张，其中４只肝外胆管柱状扩张，而Ｐ组７只中３只胆管形态正常；②Ｐ组发生胆囊粘膜增生改变的动物数量较Ｂ组多（Ｐ＜０．０５）。③Ｐ组的胆囊上皮细胞ＤＮＡ含量，ＡｇＮＯＲｓ和蛋白质总量升高的程度较Ｂ组大，而且，均与对照组相差显著（Ｐ＜０．０５）。结论ＡＰＢＤＵ是胆囊增生性病变的关键因素之一，尤其是Ｐ型ＡＰＢＤＵ。Purpose To discuss the relationships between the APBDU x ray findings and the proliferating activities of gallbladder epithelia. Methods 19 dogs were divided randomly into P、B and C groups, every dog was taken a gallbladder biopsy and choledopancreaticography timely, and the examinations of DNA content、 AgNORs and protein content of bioptic specimens were performed.Results ①The extra or/and intra hepatic bile ducts in 6 of 7 dogs of group B dilated, and in 3 of 7 dogs of group P were normal.② There were much more proliferating changes of gallblandder mucosae in group P than those in group B ( P <0.05).③ The degrees of increment of DNA content、AgNORs and protein content of gallbladder epithelia in group P were higher than those in group B, and these indices in both group P and group B are higher than those in group C. Conclusion APBDU is one of the key factors to proliferating disease in gallbladder, as far as type P is concerned, the proliferating activeity of gallbladder epithelium is especially high. [

关 键 词：异常胆胰管连接 X线 病因学 胆囊上皮 细胞增殖 

分 类 号：R657.440.6[医药卫生—外科学] R657.402[医药卫生—临床医学]