活血化瘀类中药逆转多药耐药作用的研究概况  

Advances in studies on reversion of multidrug resistance of tumors by the blood activating stasis removing drugs of traditional Chinese medicine

作　　者：雷宇[1] 李森[1] 林霖[1] 马永钢[1] 

机构地区：[1]南开大学药学院,天津300071

出　　处：《药物评价研究》2010年第2期135-138,共4页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(30950014);天津市应用基础与前沿技术研究计划一般项目(08JCYBJC25900)

摘　　要：肿瘤的多药耐药(multidrug resistance,MDR)是肿瘤化疗失败的主要原因之一。中草药以其多成分,多作用机制的优势在我国肿瘤临床治疗方面获得了广泛的应用,其中活血化瘀类中药是常用的一类药物,目前已经发现该类中药对肿瘤细胞的多药耐药具有逆转作用。现就MDR的发生机制和活血化瘀类中药制剂逆转MDR的研究作一综述。Multidrug resistance of tumors （MDR） is one of the main reasons for the failure of chemotherapy. Chinese herbal medicine was widely used in Chinese clinical cancer therapy because of its advantages of multi-component, multi-mechanism. The Blood Activating Stasis Removing Drugs of traditional Chinese medicine is commonly used, and its reversal activity on the tumor cells has been observed. In this review, the current research progress on the mechanism of multiple drug resistance and reversion by the Blood Activating Stasis Removing Drugs are described.

关 键 词：肿瘤 多药耐药 逆转剂 活血化瘀类中药 

分 类 号：R979.1[医药卫生—药品] R730.52[医药卫生—药学]