缅甸拉咱市间日疟对氯喹的敏感性评价  

Evaluation of the sensitivity of vivax malaria to chloroquine in the City of Laza,Myanmar

作　　者：梁桂亮 孙晓东[2] 王剑[2] 张再兴[2] 

机构地区：[1]昆明市第三人民医院检验科,云南昆明650041 [2]云南省寄生虫病防治所/云南省疟疾研究中心,云南普洱665000

出　　处：《中国病原生物学杂志》2010年第5期362-363,372,共3页Journal of Pathogen Biology

摘　　要：目的观察缅甸拉咱市间日疟对氯喹的敏感性。方法 54例间日疟患者镜检原虫密度≥500个原虫/μl全血,2周内未服用过抗疟药物或四环素和磺胺类等有抗疟作用的药物。患者给予氯喹25mg(含基质)/kg体重,口服,连续3d,同时伍用伯喹0.25mg(基质)/kg体重,连续14d。于服药当天、服药后第1、2、3、7、14、21和28d和6个月对患者进行观察和随访。结果 54例间日疟患者的平均退热时间为(23.46±11.40)h,原虫无性体平均转阴时间为(35.93±12.62)h。所有患者原虫无性体和配子体3d内全部转阴,1例患者疑出现氯喹一级抗性。结论缅甸拉咱市现症间日疟患者对氯喹敏感。Objective To ascertain the sensitivity of vivax malaria to chloroquine in the City of Laza,Myanmar. Methods Subjects were 54 patients with a parasite density equal to or over 500/μl blood who had not taken any drugs as might be effective in treating malaria in the past 2 weeks. Patients were given chloroquine （base） at a dose of 25 mg/kg body weight for 3 days and primaquine （base） at a dose of 0.25 mg/kg for 14 days. Patients were observed and followed up on D0,D1,D2,D3,D7,D14,D21,and D28 and M6. Results In the 54 patients,the mean parasite clearance time was （35.93±12.62） h and the mean fever clearance time was （23.46±11.40） h. Asexual parasites and gametocytes were cleared from all patients. One patient was suspected of manifesting strong resistance to chloroquine. Conclusion Vivax malaria is sensitive to chloroquine in patients in the City of Laza,Myanmar.

关 键 词：间日疟 氯喹 伯喹 敏感性 复发 

分 类 号：R531.3[医药卫生—内科学]