复方通络胶囊预处理大脑中动脉缺血再灌注大鼠后脑组织NOS SOD活性和MDA含量变化  

Change of NOS SOD Activity and MDA Content of Brain Tissue In Middle Cerebral Artery Ischemia-Reperfusion Rats Pretreated by Fufangtongluo Capsule

作　　者：肖婧[1] 王敬卿[2] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]南京市中医院,江苏南京210001

出　　处：《辽宁中医药大学学报》2010年第6期76-77,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：南京市卫生局医学课题(YKK0456)

摘　　要：目的:观察复方通络胶囊对大脑中动脉缺血再灌注(MCAO)大鼠的预防性脑保护作用。方法:采用MCAO大鼠模型,造模前大鼠灌胃给药1周,以脑组织一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量为指标,观察复方通络胶囊对MCAO大鼠的作用机理。结果:复方通络胶囊能明显降低模型动物MDA含量,提高SOD活性,与模型组比较有显著性差异(P<0.05,P<0.01),并且能降低NOS活性。结论:复方通络胶囊能够降低模型动物NOS活性和MDA含量,提高SOD活性,对MCAO大鼠有预防性脑保护作用。Objective：To observe the brain preventively protective effect of Fufangtongluo capsule on middle cerebral artery ischemia-reperfusion（MCAO）rats.Methods：The MCAO rats are fed with Fufangtongluo capsule by gavage before operated.Then we observe the brain tissue nitric oxide synthase（NOS）,superoxide dismutase（SOD）activity and malondialdehyde（MDA）content as indicators to observe the mechanism of Fufangtongluo capsule effect on the MCAO rats.Results ：Fufangtongluo capsule can significantly reduce MDA content,increase SOD activity,compared with the model group（P0.05,P0.01）,and reduce NOS activity.Conclusion ：Fufangtongluo capsule can reduce NOS activity and MDA content and increase SOD activity,which has preventive cerebral protection to MCAO rats.

关 键 词：复方通络胶囊 大脑中动脉缺血再灌注 NOS MDA SOD 

分 类 号：R285[医药卫生—中药学]