逍遥丸对高架十字迷宫小鼠行为影响的实验研究  

Experimental Research about the Effect of Xiaoyao Pill on Behavior of EPM Mice

作　　者：韦史利[1] 赵学军[1] 

机构地区：[1]广州中医药大学新药开发与研究中心,广东广州510006

出　　处：《辽宁中医药大学学报》2010年第6期265-266,共2页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:通过小鼠高架十字迷宫实验,了解逍遥丸的抗焦虑作用。方法:连续给予逍遥丸7天后,进行高架十字迷宫实验。记录动物的OE、CE、OT、CT、HD和RE值等指标。结果:逍遥丸3个剂量均能提高高架十字迷宫小鼠的OE+CE、OE/(OE+CE)、OT/(OT+CT)值,降低RE、HE值,并且存在一定的量效关系,其中高剂量组的效果最好。结论:逍遥丸具有明显的抗焦虑作用。Objective：To study the anti-anxiety effects of Xiaoyao pill on EPM mice by the EPM experiments.Methods ：Xiaoyao pill was given to mice for seven days,and OE,CE,OT,CT,HD,RE were recorded.Result ：Three doses of Xiaoyao pill all can increase the EPM mouse OE＋CE,OE/（OE＋CE）,OT/（OT＋CT）,lower RE,HE value,and there is a certain degree of dose-effect relationship,in which high-dose group is the best.Conclusion ：Xiaoyao pill has the effect of anti-anxiety.

关 键 词：逍遥丸 高架十字迷宫 抗焦虑 

分 类 号：R285[医药卫生—中药学]