补肾复方对压力负荷增加大鼠心肌局部血管紧张素Ⅱ水平的影响  

Influnnce of Bu Shen Prescription on local angiotensin Ⅱin myocardial tissues of rats with pressure overload

作　　者：董晓蕾[1] 张群燕[1] 赵智明[1] 郭郡浩[1] 商玮[1] 蔡辉[1] 

机构地区：[1]南京军区南京总医院中西医结合科,江苏南京210002

出　　处：《蚌埠医学院学报》2010年第5期440-442,共3页Journal of Bengbu Medical College

基　　金：南京军区南京总医院科研基金资助项目(Q2008042)

摘　　要：目的:观察补肾复方对压力负荷增加大鼠左心室心肌局部血管紧张素Ⅱ(AngⅡ)水平的影响,探讨补肾复方逆转左心室重构的可能机制。方法:造模,将60只大鼠随机分为假手术组、模型组、卡托普利组、补肾复方大剂量组及补肾复方小剂量组,每组12只。观察5组左心室重量指数(LVMI)及病理形态。采用放射免疫分析法测定左心室心肌局部AngⅡ水平。结果:模型组LVMI、左心室心肌局部AngⅡ水平较假手术组显著升高(P<0.01);卡托普利组、补肾复方大剂量组和小剂量组均明显低于模型组(P<0.01)。除模型组外,余4组心肌病理形态改变类似。结论:补肾复方与卡托普利具有基本一致的延缓压力负荷大鼠左心室重构的作用,其作用可能与减少左心室心肌局部AngⅡ水平有关。Objective：To observe the influence of Bu Shen Prescription on the level of local angiotensin Ⅱ（AngⅡ）in the left ventricular myocardial tissue of rats with pressure overload,and to study the possible mechanism of regressing the left ventricular remodeling.Methods：Sixty SD male rats were randomly divided into five groups：shan operatien group,untreated group,captopril group,Bushen prescription high dosage group and the low dosage group,12 rats in each group.Left venticular mass index（LVMI）was measured,and pathological morphology was observed.Radioimmunoassay was used to detect the local AngⅡlevel of the left ventricular myocardial tissue.Results：The AngⅡ level of the left ventricular myocardial tissue in model group was higher than that of sham operation group（P〈0.01）.In captopril group,Bu Shen Prescription high dosage group and low dosage group,the AngⅡ level was lower than that in model group（P〈0.01）.The left ventricular myocardial pathological morphology was similar except untreated group.Conclusions：Bu Shen Prescription and captopril have similar effects in regressing the left ventricular remodeling in rats with pressure overload,which may be concerned with the decrease of local AngⅡ level of the left ventricular myocardial tissue.

关 键 词：血管紧张素Ⅱ 左心室重构 压力负荷 补肾复方 大鼠 

分 类 号：R972.5[医药卫生—药品]