急性冠状动脉综合征患者血清可溶性E-选择素和白介素-10水平的变化及其与冠状动脉病变程度的相关性  

Correlation between serum soluble E-selectin,interleukin-10 and the degree of coronary artery lesions in acute coronary syndrome

作　　者：汤凤英[1,2] 马礼坤[1] 石增刚[2] 桑更生[2] 

机构地区：[1]安徽医科大学附属省立医院心血管内科,安徽合肥230001 [2]安徽省蚌埠市第三人民医院心血管内科,安徽蚌埠233000

出　　处：《蚌埠医学院学报》2010年第5期456-458,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨急性冠状动脉综合征(acute coronary syndrome,ACS)血清可溶性E-选择素(soluble E-selectin,SES)、白介素-10(interleukin-10,IL-10)水平变化及其与冠状动脉病变程度的相关关系。方法:选择冠状动脉造影患者94例,分为ACS组39例,稳定型心绞痛组(SAP)组23例,正常对照组32例,应用ELISA法测定患者血清SES、IL-10水平;免疫比浊法检测血清超敏C反应蛋白(high-sensitive creactive protein,hs-CRP)。结果:ACS组血清SES、IL-10和hs-CRP水平均明显高于SAP组和对照组(P<0.01)。SAP组SES和hs-CRP水平与对照组比较差异均无统计学意义(P>0.05)。SES、IL-10与冠状动脉病变数量及冠状动脉病变程度均无明显的相关关系(P>0.05)。结论:ACS患者血清SES和IL-10水平明显增高,提示其与斑块的不稳定性有关,而与冠状动脉病变程度无关。Objective：To explore the correlation between the levels of soluble E-selectin（SES）,interleukin-10（IL-10）and the degree of coronary artery stenosis in acute coronary syndrome（ACS）.Methods：Ninety-four patients receiving coronery artery angiography were divided into ACS group（39 cases）,stable angina pectoris（SAP）group（23 cases）and control group（32 cases）.The serum levels of SES and IL-10 were measured by ELISA,and the high-sensitive creactive protein（hs-CRP）was dertermined by immunoturbidimetry.Results：The serum levels of SES and hs-CRP in ACS group were significantly higher than those in SAP group and control group（P〈0.01）;the serum levels of SES and hs-CRP in SAP group had no significant difference compared with those of the control（P〈0.05）.SES and IL-10 had no obvious correlation with the count of coronary athey stenosis or the degree of coronary artery stenosis（P〉0.05）.Conclusions：Increased serum levels of SES and IL-10 may reflect the instability of atherosclerotic plaques but not the degree of coronary artery stenosis in acute coronary syndrome.

关 键 词：心肌缺血 急性冠状动脉综合征 心绞痛 E-选择素 白介素-10 

分 类 号：R541[医药卫生—心血管疾病]