速降糖对实验性糖尿病大鼠周围神经病变防治作用的实验研究  

Experimental investigation of the protective effect on the diabetic peripheral neuropathy of SJT

作　　者：吴洁[1] 

机构地区：[1]第三军医大学西南医院老年科,重庆400038

出　　处：《重庆医学》2010年第11期1377-1379,共3页Chongqing medicine

摘　　要：目的研究速降糖对实验性糖尿病大鼠周围神经病变的防治作用,为临床用药和进一步开发提供更多实验理论依据。方法以链脲佐菌素(STZ)诱发糖尿病周围神经病变模型。连续治疗8周后,检测血液流变学的变化、神经传导速度的改变、海马区神经生长因子(NGF)表达情况、神经病理超微结构的改变等。结果速降糖和西药各治疗组全血粘度以及红细胞聚集指数、刚性指数较模型组显著降低(P<0.01),治疗组的MNCV和SNCV均较模型组加快(P<0.05),各治疗组海马区NGF阳性细胞数较模型组增加(P<0.01),治疗组有髓神经纤维病理超微结构改变较模型组轻。结论速降糖对实验性糖尿病大鼠周围神经病变具有一定的防治作用。Objective To investigate the mechanism of the protective effect on the diabetic peripheral neuropathy of SJT and provide an experimental basis for further investigating and clinical use.Methods The diabetes rats were induced by injecting Streptozotocin（STZ）.After eight weeks,the hemorrheology,the nerve conduction velocity,expression of NGF,and ultrastructure of each group were tested.Results The whole blood viscosity,index of red cell（RBC） aggregation and index of RBC rigidity of the high dosage group significantly decreased than those of model group.The NCV of the high dosage group was distinctly faster than that of the model group.Compared with the model group,SJT could obviously increase the expression of NGF in the hippocampus.The high dosage group could markedly protect ultrastructure of myelinated nerve.Conclusion SJT can significantly improve the function of nerve and protect the ultrastructure of myelinated nerve.

关 键 词：速降糖 实验性糖尿病 周围神经病变 超微结构 

分 类 号：R285.5[医药卫生—中药学]