老年阻塞性睡眠呼吸暂停低通气综合征合并高血压的炎症机制研究  

Inflammatory factors in senile patients with obstructive sleep apnea syndrome and hypertension

作　　者：王璋[1] 司良毅[1] 李学军[1] 

机构地区：[1]第三军医大学西南医院老年病科,重庆400038

出　　处：《重庆医学》2010年第11期1382-1383,共2页Chongqing medicine

摘　　要：目的观察老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血中炎性因子浓度与OSAHS合并高血压的关系,揭示炎症因子在OSAHS合并高血压发病机制中的作用。方法病例对照研究,分为OSAHS组与OSAHS合并高血压组。通过多导睡眠图(PSG)明确诊断中重度OSAHS的老年男性患者80例,其中40例为OSAHS合并高血压患者。用ELISA法检测血清中TNF-α、hp-CRP浓度。结果 OSAHS合并高血压患者TNF-α、hp-CRP浓度水平均显著高于无高血压的OSAHS组患者,两组间差异有统计学意义(P<0.05)。结论炎性因子在OSAHS并发高血压的发生、发展过程中可能具有重要作用。Objective To study the inflammatory factors in the senile patients with moderate or severe obstructive sleep apnea syndrome（OSAHS） and hypertension.Methods Eighty elderly patients（〉60year） were divided into OSAHS group（n=40） and OSAHS with hypertension group（n=40） by the results of polysomnogram（PSG）.The serum levels of TNF-α and hp-CRP were measured by ELISA.Results The serum levels of TNF-α and hp-CRP in OSAHS with hypertension group were higher than those of OSAHS group（P〈0.05）.Conclusion The inflammatory factors level are different between OSAHS patients with hypertension and without,which may play a role in the development of hypertension in OSAHS patients.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 炎症因子 高血压 

分 类 号：R766[医药卫生—耳鼻咽喉科]