轴突反射介导电刺激大鼠肋间神经引起的胃粘膜血流增加  

Axon reflex mediated increase in gastric mucosal blood flow induced by electric stimulation of intercostal nerve in rats *

作　　者：赵建平[1,2,3] 彭裕文[1,2,3] 刘才栋 李栋生[1,2,3] 

机构地区：[1]镇江医学院解剖学教研室 [2]上海医科大学解剖学教研室 [3]南京医科大学生理学教研室

出　　处：《世界华人消化杂志》1999年第1期8-9,共2页World Chinese Journal of Digestology

基　　金：国家教委博士点基金

摘　　要：目的观察电刺激大鼠肋间神经能否通过脊神经节细胞周围突分支上的轴突反射调节胃粘膜血流（ＧＭＢＦ）．方法切断大鼠（１０只）左侧Ｔ１０或Ｔ１１肋间神经及其神经根，用氢气清除法测定电刺激（刺激强度１２Ｖ，波宽０２ｍｓ，频率４０Ｈｚ，刺激时间２ｍｉｎ～３ｍｉｎ）肋间神经近侧断端前后的ＧＭＢＦ量．结果ＧＭＢＦ量电刺激后（６５６ｍＬ·ｍｉｎ－１·ｋｇ－１±１７７ｍＬ·ｍｉｎ－１·ｋｇ－１）比电刺激前（４９５ｍＬ·ｍｉｎ－１·ｋｇ－１±１３２ｍＬ·ｍｉｎ－１·ｋｇ－１）有显著性增加（Ｐ＜００１）．AIM To investigate whether electric stimulation of the intercostal nerve can regulate gastric mucosal blood flow (GMBF) via axon reflex based on dichotomizing branches of the peripheral processes of the spinal ganglia in rats. METHODS In 10 rats, the left T10 or T11 intercostal nerves and its roots were cut, and GMBF was measured by hydrogen gas clearance technique before and after electric stimulation (at strength 12V, pulse duration 0 2ms, frequency 40Hz for 2min-3min) delivered to the proximal cut end of the intercostal nerve. RESULTS The mean value (656mL·min -1 ·kg -1 ±177mL·min -1 ·kg -1 ) of GMBF after electrical stimulation increased significantly as compared with that (495mL·min -1 ·kg -1 ±132mL·min -1 ·kg -1 ) of GMBF before ( P <0 01). CONCLUSION Axon reflex mediates increase in GMBF induced by electric stimulation of the intercostal nerve in rats.

关 键 词：胃粘膜 生理学 电刺激 肋间神经 电生理学 

分 类 号：R333.2[医药卫生—人体生理学]