腹腔化疗在大肠癌术后的应用  

Application of intraabdominal chemotherapy to the patient with colorectal cancer after operation

作　　者：江拥军[1] 段群欢[1] 

机构地区：[1]永州市人民医院肿瘤科

出　　处：《中国普通外科杂志》1999年第1期17-19,共3页China Journal of General Surgery

摘　　要：目的探讨腹腔化疗在大肠癌术后的应用价值。方法对１９９１年１月～１９９５年１２月大肠癌术后行静脉化疗（４８例）或静脉化疗加腹腔化疗（７６例）的临床资料进行分析。结果其中术后单纯静脉化疗组的１，３，５年生存率分别为５５３２％，３０８８％，２２７１％；术中、术后行静脉化疗加腹腔化疗１，３，５年生存率分别为７８３８％，５７８４％，４２７０％，差异非常显著（Ｐ＜０．０１）。结论腹腔化疗能有效降低大肠癌术后腹腔种植及肝转移的发生率，从而提高生存率，且操作方法简单，安全有效。Objective To evaluate the effect of intra abdominal chemotherapy (IAC) in the patient with colorectal cancer (CRC) after operation. Methods The clinical data of 112 patients with CRC who underwent cancer resection from January 1991 to December 1995 were analysed. Of the 112 patients, 48 were treated with intravenous chemotherapy alone (IVC group), and the others were treated with IVC and IAC (IVC and IAC group). Results In IVC group, the 1 , 3 , 5 year survival rates were 55.32%, 30.88%, 22.71% respectively; in IVC and IAC group, the 1 , 3 , 5 year survival rates were 78.38%, 57.84%, 42.7%. The result showed that the survval rates of 1 , 3 , 5 year in IVC and IAC group were much higher than that in IVC group ( P <0.01). Conclusions Intraabdominal chemotherapy after operation can decrease the rate of liver metastatic and peritoneum metastastic in patients with colorectal cnacer, and increase the survival rate of the patient. Moreover, this method is safe, effective, and very easy to operate.

关 键 词：结肠直肠肿瘤 药物疗法 术后投药 

分 类 号：R979.19[医药卫生—药品] R735.340.5[医药卫生—药学]