类风湿关节炎患者类风湿因子、抗环瓜氨酸多肽抗体检测的诊断价值  

The diagnosis value of rheumatoid factor and anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis

作　　者：郭兆军[1] 周伟[2] 

机构地区：[1]淮南市第一人民医院普内科,安徽省淮南232007 [2]淮南市第一人民医院保健办,安徽省淮南232007

出　　处：《中国基层医药》2010年第10期1309-1310,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 评价类风湿因子（RF）、抗环瓜氨酸多肽抗体（抗CCP抗体）联合检验对类风湿关节炎（RA）的诊断价值.方法 选择风湿病患者125例,按设计要求分RA组78例,其他风湿病组（非RA组）47例.采用ELISA法定量检测抗CCP抗体、乳胶凝集法检测RF并进行统计学处理.结果 抗CCP抗体阳性率为66.7%,RF阳性率为74.4%,抗CCP抗体＋RF联合检测的阳性率为62.8%,抗CCP抗体＋RF联合检测与单独检测阳性率差异无统计学意义,但联合检测的特异性98.6%,阳性似然比29.2,比单独检测有明显的提高;灵敏度49.6%,阴性预测值54%,比单独检测有明显的降低.结论 联合检测能提高检测的特异性和阳性似然比,降低检测的灵敏度和阴性预测值,联合检测更具有诊断价值.Objective To evaluate the value of joint inspection of rheumatoid factor （ RF） and anti-cyclic citrullinated peptide antibodies（anti-CCP antibody） in rheumatoid arthritis（ RA）. Methods 125 patients with rheumatic disease were selected,including RA 78 cases,non-RA 47 cases. The quantitative ELISA to detect anti-CCP antibody, latex agglutination to test RF,and the data was analyzed. Results Anti-CCP antibody positive rate was 66. 7% ,RF was 74.4% Joint detection was 62.8% , single positive rate of joint detection was not statistically significant, but the specificity of joint detection was 98.6%,positive likelihood ratio was 29.2, significantly improved compared to individual testing;Sensitivity was 49.6%,negative predictive value was 54% ,significantly lower compared to test a-lone. Conclusion Combined detection was able to improve the specificity,positive likelihood ratio and reduce sensitivity , negative predictive value. It was more useful.

关 键 词：关节炎 类风湿 类风湿因子 瓜氨酸 

分 类 号：R446[医药卫生—诊断学] R593[医药卫生—临床医学]