热毒宁注射液治疗急性肺损伤的临床疗效  

The clinical effect of Redlining injection on acute lung injury

作　　者：钱风华[1] 钱义明[1] 朱亮[1] 项志兵[1] 祁丽丽[1] 赵雷[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院急诊医学科,上海市200437

出　　处：《中国基层医药》2010年第10期1318-1319,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 观察肺保护性通气联合热毒宁注射液治疗急性肺损伤的临床疗效.方法 59例急性肺损伤（ALI）患者随机对照分为肺保护性通气组（对照组,n=30）和肺保护性通气联合热毒宁注射液治疗组（治疗组n=29）,观察两组的临床生命体征、呼吸（RR）、血气分析等改变,进行PaO2和PaO2/FiO2比较、疗效评价及住院期间病死率统计分析.结果 治疗组患者肺损伤得到控制者21例（72.41%）,与对照组的14例（46.67%）比较差异有统计学意义（P〈0.05）;治疗组PaO2上升,PaO2/FiO2显著上升（P〈0.01）.病死率治疗组为24.14%明显低于对照组的50.00%（P〈0.05）.结论 热毒宁注射液对急性肺损伤肺保护性通气具有改善肺功能作用,并可降低住院病死率.Objective To evaluate the clinical effect of the lung protective ventilation combining with Re-duning injection on the acute lung injury （ALI）. Methods 59 patients with ALI were randomly divided into the lung protective ventilation group （control group, n =30） and the lung protective ventilation wmbined with Reduning injection group（experimental group,n = 29） ,and the changes of vital signs,RR,blood gas analysis,and so on were observed. The comparison between PaO2 and PaO2/FiO2 was carried out. The efficacy and the mortality rate were evaluated. Results Lung injury in 21 cases of experimental group were improved after applied Reduning treatment（72. 41%）,there was a significant difference （ P 〈 0.05） with that of 14 cases in control group （46. 67% ） ; PaO2 increased, PaO2/FiO2 significantly increased in experiment group,there were significant difference compared with those of control group（P 〈0. 01）. The mortality rate in the experimental group was 24.14% ,there was a significant differ-ence（P〈0.05） compared with the mortality of 50. 00% in control group. Conclusion Reduning treatment could, improve the pulmonary function in lung protective ventilation to cure ALI,reducing the mortality rate as well.

关 键 词：呼吸窘迫综合征 成人 热毒宁注射液 正压呼吸 

分 类 号：R563[医药卫生—呼吸系统]