泮托拉唑奥美拉唑与法莫替丁治疗消化性溃疡的疗效观察  

Study on effect of pantoprazole,omeprazole and famotidine on treatment of peptic ulcer

作　　者：陈经云[1] 王明霞[1] 汪和明[1] 叶启文[1] 

机构地区：[1]东莞市厚街医院,广东东莞523945

出　　处：《现代医药卫生》2010年第11期1620-1621,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨泮托拉唑、奥美拉唑与法莫替丁治疗消化性溃疡的临床效果。方法:将2007年1月～2008年1月在我院住院治疗的消化性溃疡患者随机分为泮托拉唑组、奥美拉唑组和法莫替丁组并接受相应的药物治疗,同时三组均给予常规抗菌药物治疗,评估三组治疗效果与安全性。结果:泮托拉唑组第一周疼痛消失例数占65.63%,第四周占1.56%;奥美拉唑组第一周疼痛消失人数占67.19%,第四周占1.56%;法莫替丁组第一周疼痛消失例数占46.88%,第四周占14.06%,两组与法莫替丁组分别比较差异具有统计学意义(P<0.05)。泮托拉唑组HP清除率为96.30%,奥美拉唑组为94.64%,法莫替丁组为80.00%,两组分别与法莫替丁组比较差异具有统计学意义(P<0.05)。泮托拉唑组总有效率为96.88%,奥美拉唑组为96.88%,法莫替丁组为87.50%,两组分别与法莫替丁组比较差异具有统计学意义(P<0.05)。三种药物临床不良反应发生率比较差异无统计学意义(P>0.05)。结论:泮托拉唑、奥美拉唑治疗消化性溃疡的临床效果相似,优于法莫替丁,不良反应少,值得推荐应用。Objective：To investigate the effect of pantoprazole,omeprazole and famotidine on treatment of peptic ulcer.Methods：The patients with peptic ulcer in our hospital from January 2007 to January 2008 were divided into the pantoprazole group,omeprazole group and famotidine group,each group received the corresponding drug,and at the same time,all groups received the antisepticizing treamtent.The effect and safty of pantoprazole,omeprazole and famotidine were investigated.Results：The cases of pantoprazole group with pain disappear in the first week was 65.63% and was 1.56% in the forth week,the cases of omeprazole group with pain disappear in the first week was 67.19% and was 1.56% in the forth week,the cases of famotidine group with pain disappear in the first week was 46.88% and was 14.06% in the forth week,and there was significant difference in the pantoprazole group,omeprazole group and famotidine group（P0.05）.The clearance of HP was 96.30% in pantoprazole group,94.64% in omeprazole group and 80.00% in famotidine group,and there was significant difference in the pantoprazole group,omeprazole group and famotidine group（P0.05）.The total effective rate was 96.88% in pantoprazole group,96.88% in omeprazole group and 87.50% in famotidine group,and there was significant difference in the pantoprazole group,omeprazole group and famotidine group（P0.05）.There was no significant difference on the side effect of the three drugs（P0.05）.Conclusion：The effect of pantoprazole is same to omeprazole,the effect of pantoprazole and omeprazole is superior to famotidine,and side effect of pantoprazole and omeprazole is few,so they are worth being used widely.

关 键 词：泮托拉唑 奥美拉唑 法莫替丁 消化性溃疡 

分 类 号：R5[医药卫生—内科学]