左旋肉碱治疗弱精子症患者的疗效观察  

L-carnitine:Safe and effective for asthenozoospermia

作　　者：王亚轩[1] 杨书文[1] 瞿长宝[1] 霍红旭[1] 黎玮[1] 李景东[1] 常学良[1] 蔡广增[1] 

机构地区：[1]河北医科大学第二医院泌尿外科,河北石家庄050000

出　　处：《中华男科学杂志》2010年第5期420-422,共3页National Journal of Andrology

基　　金：河北省人口和计划生育委员会资助课题(2008-1308)~~

摘　　要：目的:精子活力低下是导致男性不育的一个重要原因,目前无特效治疗措施。本研究采用左旋肉碱对弱精子症患者进行治疗,以探讨其疗效。方法:选择弱精子症患者135例,将其随机分为两组,其中A组68例,为左旋肉碱治疗组,给予左旋肉碱口服液(2g/d)和维生素E口服3个月为1疗程;B组67例,为对照组,单纯给予维生素E,疗程同前。治疗前及治疗后3个月对所有病例均进行患者精液参数分析,同时了解配偶妊娠率及不良反应发生情况。结果:与治疗前相比,A组患者治疗后前向运动精子百分率(45.4%±11.1%vs28.6%±9.2%)明显提高(P<0.01),精子密度和正常形态精子百分率虽有一定提高,但无统计学差异(P>0.05);B组患者治疗后精子活力、精子密度及正常形态精子百分率与治疗后均无统计学差异(P均>0.05)。两组间治疗后比较,A组的前向运动精子百分率(45.4%±11.1%)明显高于B组(31.3%±10.5%)(P<0.01);两组的的精子密度和正常形态精子百分率无显著性差异(P>0.05)。治疗3个月后女方妊娠者,A组19例(31.1%),B组2例(3.8%),两组存在显著差异(P<0.01)。治疗期间所有患者均未见明显不良反应。结论:左旋肉碱可以显著改善患者的精子活力,提高其配偶的妊娠率,安全有效。Objective：One of the important reasons for male infertility is asthenozoospermia,for which there is no specific cure for the time being.The authors explored the clinical effect of L-carnitine for infertile males with asthenozoospermia.Methods：A total of 135 patients with asthenozoospermia were randomly divided into Groups A （n = 68） and B （n = 67）,the former treated with L-carnitine （2 g/d） and vitamin E,while the latter with vitamin E only,both for 3 months.All the patients received semen analyses before and after the treatment,and were observed for adverse effects.The pregnancy rates of their wives were recorded.Results：Group A showed a significantly increased percentage of forward motile sperm after the treatment （45.4% ± 11.1%） as compared with pretreatment （28.6% ± 9.2%） （P0.01）,but no statistically significant differences were found in sperm density and the percentage of the sperm of normal morphology （P0.05）.The rate of pregnancy was significantly higher in Group A （31.1%） than in B （3.8%） after the treatment （P0.01）.No adverse events were found during the treatment.Conclusion：L-carnitine,capable of significantly improving sperm motility and raising the rate of pregnancy,is a safe and effective therapeutic option for asthenozoospermia.

关 键 词：弱精子症 男性 药物治疗 左旋肉碱 精液 

分 类 号：R698.2[医药卫生—泌尿科学]