氟伐他汀对充血性心力衰竭患者血清sICAM-1和sVCAM-1的影响  

Effects of fluvastatin on serum sICAM-1 and sVCAM-1 in patients with congestive heart failure

作　　者：李争[1] 马立庆[2] 朱卉[2] 黄喆[2] 吴云涛[2] 郑晓明[2] 

机构地区：[1]华北煤炭医学院附属中医医院心内科,河北唐山063000 [2]华北煤炭医学院附属开滦有限责任公司医院心内科,河北唐山063000

出　　处：《心脏杂志》2010年第3期408-411,共4页Chinese Heart Journal

摘　　要：目的:探讨氟伐他汀短期治疗对充血性心力衰竭(CHF)患者血清中可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)和肿瘤坏死因子α(TNF-α)水平的影响。方法:将97例CHF患者随机分为对照组(常规治疗组)和试药组(氟伐他汀组)。采用ELISA测定治疗前及治疗两周后血清中sICAM-1、sVCAM-1和TNF-α水平。结果:两种方法都可以明显降低血清sICAM-1、sVCAM-1和TNF-α水平(P<0.05);试药组血清TNF-α水平降低更为显著(P<0.05),但血清sICAM-1和sVCAM-1降低水平与对照组无显著差别。结论:在常规治疗基础上短期加用氟伐他汀治疗不能进一步降低CHF患者血清sICAM-1和sVCAM-1水平。AIM： To observe the effects of short-term treatment of fluvastatin on serum soluble intercellular adhesion molecule-1 （slCAM-1）, soluble vascular cell adhesion molecule-1 （sVCAM-1） and tumor necrosis factor-α （TNF-α） in patients with congestive heart failure （CHF）. METHODS： Ninety seven patients with CHF were randomly divided into control group （conventional treatment group） and test drug group （fluvastatin group）. Levels of serum slCAM-1, sVCAM-1 and TNF-α were measured using enzyme-linked immunosorbent assay （ELISA） before treatment and after 2 weeks of treatment. RESULTS： Both methods can significantly reduce serum sICAM-1, sVCAM-1 and TNF-α level （P 〈 0. 05）. TNF-α levels of test drug groups reduced more significantly （ P 〈 0.05 ） , whereas decreased levels of serum slCAM-1 and sVCAM-1 had no significant difference compared with control group. CONCLUSION： On the basis of conventional treatment together with short-term fluvastatin treatment, no further reduction of the levels of sICAM-1 and sVCAM-1 were demonstrated.

关 键 词：心力衰竭 充血性 氟伐他汀 细胞间黏附分子-1 血管细胞黏附分子-1 

分 类 号：R541.6[医药卫生—心血管疾病]