β-榄香烯衍生物的合成进展  

Progress of β-Elemene and its Derivatives

作　　者：张殊佳[1] 周鹏[1] 段华鑫[1] 袁韩[1] 

机构地区：[1]辽宁省生物有机化学重点实验室大连大学环境科学与化学工程学院,大连116622

出　　处：《化学通报》2010年第6期499-505,共7页Chemistry

基　　金：国家自然科学基金项目(30873143);辽宁省高校创新团队项目(2008T005)资助

摘　　要：β-榄香烯是从姜科植物温莪术中分离出来的、目前已应用于临床的的抗癌药物。β-榄香烯由于具有优良的抗肿瘤特性,正在日益受到人们关注。但是,β-榄香烯也有诸如活性不高、水溶性较差等不足,需要通过结构修饰加以改善。本文结合笔者的研究工作,综述了β-榄香烯卤代、含氮、酯类、糖苷等几大类衍生物的研究进展,重点介绍β-榄香烯的结构修饰工作。β-Elemene is a novel anticancer drug,which was extracted from the ginger plant and has been applied in clinics.β-Elemene exhibits excellent anti-tumor properties,it has attracted more interest.However,it is necessary to improve by structural modification due to its shortcoming such as low activity,less water-soluble etc.The syntheses about the derivatives of β-Elemene containing halogeno-,nitrogen-,esters,glycosides and so on,combined the authors＇work,are reviewed.The modifications of β-Elemene are emphatically introduced.

关 键 词：Β-榄香烯 β-榄香烯衍生物 合成 结构修饰 

分 类 号：TQ463.2[化学工程—制药化工]