电生次氯酸根流动注射化学发光法测定L-多巴  

Flow Injection Chemiluminescence Determination of L-dopa With Electrogenerated Hypochlorite

作　　者：黄嘉初[1] 张成孝[1] 章竹君[1] 

机构地区：[1]陕西师范大学化学系

出　　处：《分析化学》1999年第1期41-43,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助课题(NO.39730160)

摘　　要：将恒电流电解产生ClO^-与流动注射化学发光分析法结合,基于L多巴对ClO^-Luminol体系化学发光的抑制作用,建立了测定L多巴流动注射化学发光新分析法.该法测定L多巴的检出限为8×10^(-10)g/mL,线性范围为2×10^(-9)～1×10^(-7)g/mL,相对标准偏差为3.0%.该法具有简单、快速、灵敏的特点,应用于药片中L多巴的测定,结果满意.A flow-injection chemiluminescence method for the determination of L-dopa based on its inhibition of chemiluminescence from luminol-hypochlorite system is described. The hypochlorite was electrogenerated on-line by constant current electrolysis, thus, eliminating instability of hypochlorite solution prepared from commercially available sodium hypochlorite. The linear range for L-dopa is from 2 ×10-9to1×10-7 g/mL and the detection limit is 8 × 10 -10 g/mL. The relative standard deviation is 3.0% . The proposed method with simplicity, rapidity and sensitivity has been successfully applied to the determination of L-dopa in pharmaceutical preparations.

关 键 词：电解 流动注射 化学发光 L-多巴 测定 左旋多巴 

分 类 号：R971.5[医药卫生—药品]