超重肥胖儿童的脂代谢异常与INSIG2基因的关联研究  

Association of abnormal lipid metabolism with INSIG2 gene variant in overweight and obese children

作　　者：王海俊[1,3] 张衡[2,3] 张伋[2,3] 王燕[1] 马军 

机构地区：[1]北京大学公共卫生学院妇女与儿童青少年卫生学系,100191 [2]儿童青少年卫生研究所 [3]流行病学教育部重点实验室

出　　处：《中华流行病学杂志》2010年第6期650-654,共5页Chinese Journal of Epidemiology

基　　金：高等学校博士学科点专项科研基金（20070001811）;国家自然科学基金（30700668）;国家重点基础研究发展计划（“973”计划）（2006CB503900）

摘　　要：目的 研究儿童超重肥胖和脂代谢与胰岛素诱导基因2（INSIG2）变异的相关性.方法 选择北京市2030名7～18岁的儿童进行身体测量及血脂、INSIG2基因rs13428113多态性检测.结果 研究对象rs13428113多态性的等位基因突变率（T〉C）为49.3%.比较体重正常、超重和肥胖组基因型及等位基因频率,发现三组差异无统计学意义（P〉0.05）.在超重组中CC基因型携带者的体重指数、腰臀比、肱三头肌和髂前上棘皮褶厚度高于TT/TC基因型携带者;在肥胖组中CC携带者总胆固醇水平高于TT/TC携带者（P〈0.05）.结论 INSIG2基因rs13428113多态性与超重肥胖儿童的脂代谢异常有关,可能加重肥胖、血脂异常程度.Objective To study the relationship between insulin induced gene 2 （INSIG2） variant and obesity or lipid metabolism in Chinese children and adolescents. Methods A total number of 2030 school students at the age from 7 to 18 years were selected in Beijing. Physical indicators, serum lipids and the rs13428113 polymorphism in INSIG2 gene were examined for all the subjects. Results The overall mutation rate of the rs13428113 polymorphism （T〉 C） was 49.3%. The differences of genotype and allele frequencies were not statistically significant among normal-weight, overweight and obesity groups （P〉0.05）. Among the overweight students, those with CC genotype had higher body mass index, waist-hip ratio, bronchial triceps skin-fold, and anterior superior iliac spine skin-fold than TT/TC carriers. Among the obese group, those with CC genotype had higher total cholesterol level than TT/TC carriers （P〈0.05）. Conclusion The rs13428113 polymorphism in INSIG2 gene was associated with abnormal lipid metabolism in overweight and obese children, which increasing the degree of obesity and abnormal serum lipids.

关 键 词：肥胖 儿童 INSIG2基因 

分 类 号：R725.9[医药卫生—儿科]