畲族自然人群脉压与双侧颈动脉血管功能的关联研究  

Study on the relations between homodynamic parameters and structure of common carotid artery among the Ethnic She Population, China

作　　者：洪永强 王宏宇[2] 郑长业 黄孟华 吴秀琴 曾诚 韦朝清 李朝军[3] 

机构地区：[1]福建省宁德市闽东医院,355000 [2]北京大学首钢医院血管医学科 [3]百胜医疗设备有限公司,深圳

出　　处：《中华流行病学杂志》2010年第6期688-691,共4页Chinese Journal of Epidemiology

基　　金：卫生部十年百项计划“血管病变早期检测技术推广”项目（04-10-01）

摘　　要：目的 了解畲族自然人群双侧颈总动脉内中膜厚度（IMT）的变化,判断脉压水平对双侧颈总动脉结构影响的异同性.方法 采用＂中国动脉僵硬度评价研究＂的方法,433名畲族人来自福建省福安市城乡自然人群,年龄15～87（49.03±13.54）岁.根据该人群脉压三分位数水平分为三组：脉压≤48 mm Hg（1 mm Hg=0.133 kPa）、49～59 mm Hg和〉59mm Hg.应用超声射频信号血管内中膜分析技术（QIMT）和常规二维超声分别观察记录静息状态下双侧颈总动脉.测量舒张末期IMT,比较双侧颈动脉IMT在各组间的差异和变化趋势,分析其与年龄、体重指数、脉压、总胆固醇、甘油三酯（TG）等危险因素之间的关联.结果 （1）双侧颈动脉IMT随脉压增加而增厚,趋势检验差异有统计学意义（P〈0.01）.左侧颈总动脉（LCC）IMT在第1分位组与第2分位组间的差异无统计学意义（P〉0.05）,但均与第3分位组的差异有统计学意义（P〈0.05）.右侧颈总动脉（RCC）IMT在三组间的差异均有统计学意义（P〈0.01）.（2）多元线性回归结果表明,进入颈总动脉IMT回归方程的顺序和关联因素.左侧为年龄、脉压、体重、低密度脂蛋白胆固醇（LDL-C）、血糖和TG,其回归方程LCC-IMT=32.61＋4.29（年龄）＋1.77（脉压）＋1.87（体重）＋16.52（LDL.C）＋11.77（血糖）-9.92（TG）,r=0.663,r2=0.44,P〈0.001;右侧为年龄、脉压和身高,其回归方程RCC-IMT=5.19（年龄）＋1.61（脉压）＋2.62（身高）-219.36,r=0.636,r2=0.41,P〈0.001.结论 畲族自然人群双侧颈动脉IMT随脉压变化存在差异,与年龄、脉压、体重、LDL-C、血糖、TG和身高明显相关.Objective To study the changes of intima-media thickness （IMT） in ambi-common carotid arteries （ambi-CCA） and how they correlated with factors related to quality intima-media thickness （QIMT）. Methods According to the Chinese Arterial Stiffness Evaluation （CASE） project, the IMT of （ambi-CCA） was measured by QIMT and 2-D ultrasound respectively in 433 She people aged 15-87 （mean 49.03 ±13.54）. Difference and tendency were analyzed on age, gender, body mass index （BMI）, pulse pressure （PP）, total cholesterol （TC）, and triglyceride. The whole population was classified into 3 groups by tertiles of pulse pressure. Results （ 1 ） Significant positive correlations were found between ambi-CCA IMT and pulse pressure （P〈 0.01 ）. There was no significant difference between tertilel and tertile 2 of IMT in the left CCA（P〉0.05） found, but with significant difference among the tertile groups, respectively （P〈0.05）. There were significant differences among the three groups of IMT in the right CCA, respectively （P〈0.01）. （2） The regression factors of IMT in left CCA were age, pulse pressure, weight, LDL-C, blood glucose （BG）, TG , and theirregression equation was LCC-IMT=32.61 ＋ 4.29 （age） ＋ 1.77 （PP） ＋ 1.87 （weight） ＋ 16.52（LDL-C） ＋ 11.77（BG）-9.92（TG）, with r=0.663 and r^2=0.44, （P〈0.001）. The regression factors of IMT in right CCA were age, PP, height and their regression equation was RCC-IMT=5.19（age） ＋ 1.61 （PP） ＋2.62（height） -219.36 ,with r=0.636 and r^2=0.41 （P〈0.001）. Conclusion There were differences seen on IMT of CCA in the PP and position and were correlated with age, PP, body weight, LDL-C, BG, TC and body height. The difference of ambi-CCA should be called for attention.

关 键 词：颈总动脉 颈总动脉内中膜厚度 脉压 自然人群 

分 类 号：R543[医药卫生—心血管疾病]