血清促甲状腺激素与代谢综合征及其组分的相关关系研究  

The correlation of thyrotropin and the metabolic syndrome and its components

作　　者：王佳妮[1,2] 单忠艳[1,2] 滕卫平[1,2] 姜凤伟[1,2] 王蓓蓓[1,2] 赖亚新[1,2] 陈彦彦[1,2] 李祉丹[1,2] 单玲[1,2] 史良凤[1,2] 李宁娜[1,2] 于嘉澍[1,2] 鲁丽[1,2] 白雪[1,2] 王森[1,2] 

机构地区：[1]沈阳中国医科大学附属第一医院内分泌科 [2]中国医科大学内分泌研究所,沈阳110001

出　　处：《中国实用内科杂志》2010年第6期534-536,共3页Chinese Journal of Practical Internal Medicine

基　　金：中国光华基金会基金(奖字[2007]02号);中华医学会科研专项基金7020470055

摘　　要：目的探讨血清促甲状腺激素(TSH)与代谢综合征(MS)及其组分的关系。方法 2007年10月在沈阳市大东区分层抽样调查1534人,详细填写流行病学调查表格,测量血压、身高、体重及腰围,采集血样测定TSH、空腹血糖(FPG)、胰岛素浓度、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)。结果 MS组血清TSH明显高于非MS组(2.54mU/L对2.22mU/L,P<0.05);亚临床甲减组TG明显高于甲状腺功能正常组[(1.73±0.12)mmol/L对(1.47±0.03)mmol/L,P<0.05],HDL-C明显低于甲状腺功能正常组[(1.26±0.27)mmol/L对(1.33±0.27)mmol/L,P<0.05];亚临床甲减组高血压患病率明显高于甲状腺功能正常组(42.86%对33.2%,P<0.05)。正常范围内血清TSH与超重或肥胖的患病危险显著相关(P=0.001)。结论甲状腺功能轻度降低发生代谢综合征的危险性增加。Objective To explore the relationship between serum thyrotropin and the components of metabolic syndrome. Methods A total of 1534 adult inhabitants in Dadong district of Shenyang were asked to fulfill the questionnaires and have physical examination and oral glucose tolerance test（OGTY）. The vein blood was drawn to measure thyrotropin （ TSH）, fasting plasma glucose （ FPG ）, OGTT 2hPG, fasting insulin, triglyceride （TG） and high density lipoprotein cholesterol（HDL-C）. Results Serum TSH in the MS group was higher than in the Non-MS group（2. 54 vs 2.22 mU/L,P 〈0. 05）. TG level increased significantly in patients with subclinical hypothyroidism （SCH） compared to those with euthyroid [ （ 1.73 ± 0. 12） mmol/L vs （ 1.47 ± 0. 03 ） mmol/L, P 〈 0.05 ], and HDL-C decreased significantly compared to those with euthyroid[ （1.26 ± 0. 27 ）mmol/L vs （1.33 ± 0. 27 ） mmol/ L,P 〈 0. 05 ]. The prevalence of hypertension was higher in the SCH group than in the euthyroid group （42. 86% vs 33. 2% ,P 〈 0. 05 ）. The serum TSH within the reference range was positively related with the prevalence of overweight/obesity（P = 0. 001 ）. Conclusion Mild hypothyroidism may increase the risk of metabolic syndrome.

关 键 词：代谢综合征 促甲状腺激素 亚临床甲状腺功能减退症 

分 类 号：R5[医药卫生—内科学]