辣椒的止呕作用研究  

Study on Antiemetic Effect of Capsicum frutescens

作　　者：杨志宏[1] 岳旺[1] 刘占涛[1] 张芳[1] 王耀霞[1] 赵德雪[1] 

机构地区：[1]青岛大学医学院药学系,青岛市266021

出　　处：《中国药房》2010年第23期2113-2115,共3页China Pharmacy

基　　金：国家自然科学基金资助项目(30873108);山东省自然科学基金资助项目

摘　　要：目的:研究辣椒的止呕作用及其机制。方法:复制新型水貂呕吐模型,观察辣椒(主要成分辣椒素)对顺铂、阿朴吗啡导致的水貂呕吐行为的抑制作用,并通过免疫组化法和特异性5-羟色胺3(5-HT3)受体激动药盐酸苯甲双胍(PBG)的应用,对其机制进行初步探讨。结果:辣椒对顺铂、阿朴吗啡引起的水貂的呕吐行为有抑制作用(P<0.05);对PBG导致的水貂的呕吐行为有抑制作用(P<0.05);对水貂胃窦组织P物质的释放有抑制作用。结论:辣椒在新型水貂呕吐模型上表现出止呕作用,其机制可能与外周组织5-HT、P物质的释放及其相应受体有关。OBJECTIVE： To study the antiemetic effects of Capsicum frutescens and its mechanism.METHODS： Novel vomiting model of minks were established.Inhibition effect of C.fruescens（capsicin as main component） on vomiting behavior induced by cisplatin and apomorphine were observed.The mechanism was investigated through the immunohistochemistry test and the specific 5-HT3-receptor agonist 1-phenylbiguanide hydrochloride（PBG）.RESULTS： C.frutescens inhibited vomiting behavior of minks induced by cisplatin and apomorphine（P0.05）.C.fruescens inhibited the emetic actions of minks induced by PBG （P0.05）.The distribution of the substance P （SP） in the muscular layer of sinus ventriculi was diminished.CONCLUSION： C.fruescens shows an antiemetic effect on novel vomiting model of minks.The mechanisms may be associated with the release of 5-HT and SP in the peripheral tissues and related receptors.

关 键 词：辣椒 止呕作用 5-羟色胺 P物质 水貂 

分 类 号：R285.5[医药卫生—中药学] R975.4[医药卫生—中医学]