湿法粉碎提取精制冠心颗粒工艺的研究  

Study on Shattering Extraction with Solvent for Jingzhi Guanxin Granules

作　　者：李巧如[1] 郭萍[1] 宋文惠[1] 赵波[1] 

机构地区：[1]陕西省人民医院药剂科,西安市710068

出　　处：《中国药房》2010年第23期2136-2138,共3页China Pharmacy

基　　金：陕西省科学技术研究发展计划项目(2008K16-04)

摘　　要：目的:优选精制冠心颗粒的提取工艺。方法:分别采用湿法粉碎提取法、回流提取法和原工艺,以丹参酮ⅡA、丹酚酸B、芍药苷、阿魏酸、羟基红花黄色素A含量及出膏率为指标,优选精制冠心颗粒的最佳提取工艺。结果:最佳提取工艺为取精制冠心方药材粗粉,第1次加6倍量95%乙醇,粉碎提取10min;第2次加6倍量60%乙醇,粉碎提取10min;第3次加6倍量20%乙醇,粉碎提取10min。结论:精制冠心颗粒湿法粉碎提取工艺,各成分提出量比原工艺明显提高,具有节约时间、操作简单的优点。OBJECTIVE： To optimize the extraction technology of Jingzhi guanxin granules.METHODS： The extraction technology of Jingzhi guanxin granules were optimized using shattering extraction with solvent,refluxing extraction and primary extraction with the content of tanshinone ⅡA,salvianolic acid B,paeoniflorin,ferulate and hydroxysafflor yellow A and extraction rate as index.RESULTS： The optimal extraction process was as follows： Jingzhi guanxin powder,6 fold 95% alcohol,extracting for 10 min in the first time,6 fold 60% alcohol,extracting for 10 min in the second,6 fold 20% alcohol,extracting for 10 min in the third.CONCLUSION： Using shattering extraction with solvent for Jingzhi guanxin granules,extraction rate of each constituent are higher than that of primary extraction.This extraction process is simple in operation and save time.

关 键 词：湿法粉碎 提取工艺 精制冠心颗粒 

分 类 号：R283[医药卫生—中药学] R97[医药卫生—中医学]