溃结愈灌肠剂的制备及质量标准研究  

Study on Preparation and Quality Standard of Kuijieyu Enemas

作　　者：张新广[1] 王冬梅[1] 丁少波[1] 

机构地区：[1]广东东莞市人民医院,东莞市523018

出　　处：《中国药房》2010年第23期2144-2146,共3页China Pharmacy

摘　　要：目的:制备溃结愈灌肠剂并建立其质量标准。方法:原方大部分药材水煎煮,部分药材粉碎,然后浓缩制成灌肠剂。用薄层色谱(TLC)法对处方中的葛根、黄连、黄芩进行定性鉴别;采用高效液相色谱法对制剂中的黄芩苷进行含量测定。结果:TLC定性鉴别斑点清晰,分离度好,专属性强。黄芩苷进样量在210～1750μg范围内与峰面积积分值呈良好线性关系(r=0.9999);平均回收率为99.13%,RSD=1.1%(n=6)。结论:本制剂制备方法简便,质量控制方法简单、可靠、专属性强、重复性好。OBJECTIVE： To prepare Kuijieyu enemas and establish its quality standard.METHODS： Most of traditional Chinese medicines in prescription were decocted using water and some were crushed.Then they were concentrated to prepare enemas.Pueraria lobata,Rhizoma Coptidis,Scutellaria baicalensis in Kuijieyu enemas were qualitatively identified by TLC.The content of baicalin in Kuijieyu enemas was determined by HPLC.RESULTS： The TLC spots were clear,well-separated and specific.The linear range of baicalin were 210～1 750 μg（r=0.999 9） with an average recovery of 99.13% （RSD=1.1%,n=6）.CONCLUSION： The preparation process is simple and convenient.The quality control method is simple,reliable,specific and reproducible.

关 键 词：溃结愈灌肠剂 制备 质量标准 黄芩苷 薄层色谱法 高效液相色谱法 

分 类 号：R283[医药卫生—中药学] R927[医药卫生—中医学]