感咳双清胶囊中黄芩苷在中国健康志愿者体内的药动学研究  

Study on Pharmacokinetics of Baicalin in Ganke Shuangqing Capsule in Chinese Healthy Volunteers

作　　者：杨昌永[1] 赵冲[1] 申理[1] 谢珍国[1] 毛棉[2] 陈重华[1] 

机构地区：[1]四川大学华西药学院药理教研室,成都市610041 [2]四川大学华西药学院临床药学教研室,成都市610041

出　　处：《中国药房》2010年第23期2186-2188,共3页China Pharmacy

摘　　要：目的:研究感咳双清胶囊中黄芩苷在中国健康志愿者体内的药动学。方法:8名健康志愿者单次口服1.8g感咳双清胶囊,采用高效液相色谱法检测血药浓度,应用DAS软件计算药动学参数。结果:口服1.8g感咳双清胶囊的主要药动学参数分别为t1/2z=(3.304±0.614)h;tmax=(8.0±0.0)h;Cmax=(2.214±0.363)mg·L-1,AUC(0～24)=(18.914±4.064)mg·h·L-1;AUC(0～∞)=(19.291±4.110)mg·h·L-1。其动力学过程符合二室模型。结论:黄芩苷在体内吸收和消除较慢,达tmax所需时间长。OBJECTIVE： To study pharmacokinetics of baicalin in Ganke shuangqing capsule in Chinese healthy volunteers.METHODS： A total of 8 healthy volunteers were enrolled in this study in which the subjects were received single dose of 1.8 g Ganke shuangqing capsule.The plasma concentrations of baicalin were determined by HPLC and the pharmacokinetic parameters were calculated with DAS software.RESULTS： The main pharmacokinetic parameters of baicalin were as follows：t1/2z：（3.304±0.614） h;tmax：（8.0±0.0） h;Cmax：（2.214±0.363） mg·L-1;AUC（0-24）：（18.914±4.064） mg·h·L-1;AUC（0-∞）：（19.291±4.110） mg·h·L-1.The pharmacokinetic process was in line with two-compartment model.CONCLUSION： The absorption and elimination of baicalin are slow and it takes a long time to reach tmax.

关 键 词：感咳双清胶囊 黄芩苷 药动学 高效液相色谱法 

分 类 号：R969.1[医药卫生—药理学] R944[医药卫生—药学]