妊娠期高血压疾病血浆GMP-140水平及Fg含量测定的临床意义  

Measurement GMP-140 and Fg in patients with hypertensive disorders complicating pregnancy

作　　者：张树荣[1] 杨淑莉[2] 李玉红[1] 何顺安[1] 

机构地区：[1]深圳市南山区妇幼保健院产科,广东深圳518052 [2]吉林大学第二医院妇产科,吉林长春130041

出　　处：《中国实用妇科与产科杂志》2010年第6期452-454,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：深圳市南山区2008年科技计划项目(南卫2008027)

摘　　要：目的探讨血栓前状态与妊娠期高血压疾病发生发展的关系。方法使用流式细胞术(FC)及PT-der法,测定2007年8月至2009年12月吉林大学第二医院及深圳市南山区妇幼保健院收治的妊娠期高血压疾病患者103例(研究组)和正常妊娠晚期孕妇30例(对照组)的产前、产后静脉血浆α-颗粒膜蛋白140(GMP-140)和纤维蛋白原(Fg)水平。将研究组的上述指标与对照组进行比较、将各组产前、产后指标进行比较。结果 GMP-140浓度子痫前期重度组与轻度组相比差异有统计学意义(P<0.05);与妊娠期高血压组及正常晚孕组相比差异有统计学意义(P<0.01)。子痫前期轻度组与正常晚孕组相比差异有统计学意义(P<0.05)。子痫前期重度组Fg含量与妊娠期高血压组相比差异有统计学意义(P<0.05);与正常晚孕组相比差异有统计学意义(P<0.01)。子痫前期重度组血浆GMP?140及Fg含量产后比产前增高,差异有统计学意义(P<0.05)。结论妊娠期高血压疾病患者存在血栓前状态,随妊娠期高血压疾病的病情加重血浆GMP-140水平及Fg含量逐渐增高,产后24小时内仍是血栓病的高发时期。Objective To discuss the relationship between the pre-thrombotic state and the occurrence and development of hypertensive disorders complicating pregnancy. Methods The antepartum and postpartum von plasma platelet alpha granule membrane protein 140 and fibrinogen （Fg） were measured by flow cytometry and PT-der in 103 hypertensive disorders complicating pregnancy and 30 term pregnant women as controls. The outcomes of gestational hypertension group, mild-preeelampsia group, heavy-preeclampsia group were compared with that of control group. The antepartum and postpartum outcome of every group were compared. Results The levels of GMP-140 was different between heavy-preeclampsia group and that of mild -preeclampsia group （ P 〈 0.05 ）. The levels of GMP-140 in heavy-preeclampsia group was higher obviously than that of the control group and the hypertensive disorders complicating pregnancy group（ P 〈 0.01 ）. The levels of GMP-140 was different between the mild -preeclampsia group and the control group（ P 〈 0. 05 ）. The levels of Fg was different between heavy-preeclampsia group and that of the hypertensive disorders complicating pregnancy group （ P 〈 0.05 ）, was higher obviously than that of the control group （ P 〈 0.01 ）. Significant positive relation exist between GMP-140 and Fg（ P 〈0. 01 ）. Significant positive relation exist between GMP-140 and Fg（ P 〈 0. 01 ）. The change between antepartum and postpartum：the GMP-140 and Fg level were obviously descend in heavy-preeclampsia（P 〈0.05 ）. Conclusion There is increased markers of prothrombotic state in patients with hypertensive disorders complicating pregnancy. The amount of GMP-140 and Fg were higher as the bad condition. The time of 24 hours after birth was the period of high incidence of thrombosis.

关 键 词：妊娠期高血压疾病 血栓前状态 血小板仪颗粒膜蛋白140 纤维蛋白原 

分 类 号：R71[医药卫生—妇产科学]