ANTIBACTERIAL POLY(D,L-LACTIDE)(PDLLA)FIBROUS MEMBRANES MODIFIED WITH QUATERNARY AMMONIUM MOIETIES  

作　　者：李新松 K.G.Neoh 

机构地区：[1]School of Chemistry and Chemical Engineering,Southeast University [2]Department of Chemical and Biomolecular Engineering,National University of Singapore

出　　处：《Chinese Journal of Polymer Science》2010年第4期581-588,共8页高分子科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.50573011 and 50673019);Southeast University Foundation(Nos.9207040015 and 4022001023)

摘　　要：Antibacterial poly（D,L-lactide） （PDLLA） fibrous membranes were developed via electrospinning, followed by surface modification which involved plasma pretreatment, UV-induced graft copolymerization of 4-vinylpyridine （4VP） and quaternization of the grafted pyridine groups with hexylbromide. The success of modification with quaternized pyridinium groups on the PDLLA fibrous membranes was ascertained by X-ray photoelectron spectroscopy （XPS）. The antibacterial activities of these membranes were assessed against Gram-positive Staphylococcus aureus （S. aureus） and Gram-negative Escherichia coli （E. coli）. The PDLLA fibrous membranes modified with quatemized pyridinium groups showed antibacterial efficiency against both bacteria as high as 99.999%. The results demonstrated that the antibacterial activity was based on the interaction of the positive charge of pyridinium group and negatively charged cell membrane of bacteria, resulting in loss of membrane permeability and cell leakage.Antibacterial poly（D,L-lactide） （PDLLA） fibrous membranes were developed via electrospinning, followed by surface modification which involved plasma pretreatment, UV-induced graft copolymerization of 4-vinylpyridine （4VP） and quaternization of the grafted pyridine groups with hexylbromide. The success of modification with quaternized pyridinium groups on the PDLLA fibrous membranes was ascertained by X-ray photoelectron spectroscopy （XPS）. The antibacterial activities of these membranes were assessed against Gram-positive Staphylococcus aureus （S. aureus） and Gram-negative Escherichia coli （E. coli）. The PDLLA fibrous membranes modified with quatemized pyridinium groups showed antibacterial efficiency against both bacteria as high as 99.999%. The results demonstrated that the antibacterial activity was based on the interaction of the positive charge of pyridinium group and negatively charged cell membrane of bacteria, resulting in loss of membrane permeability and cell leakage.

关 键 词：Poly（D L-lactide） ANTIBACTERIAL Electrospinning Surface modification 

分 类 号：R318.0[医药卫生—生物医学工程]