5例痔血胶囊致急性药物性肝损害不良反应分析  

Analysis of 5 Reports of Acute Liver Damage Induced by Zhixue Capsule

作　　者：杨婉花[1] 何娟[1] 

机构地区：[1]上海交通大学附属瑞金医院药剂科,200025

出　　处：《中国药物警戒》2010年第6期375-376,共2页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨痔血胶囊致肝损害的特点和规律。方法采用回顾性研究方法,5例痔血胶囊致急性肝损害不良反应报告进行综合分析。结果患者均按规定口服用药,平均用药时间为(22+12)天。临床表现为黄疸、乏力、发热、上腹部不适、恶心、纳差、食欲减退;肝功能检查:丙氨酸氨基转移酶(ALT)在599～3380U/L之间,总胆红素(TBIL)在5.6～489μmol/L之间;嗜酸性粒细胞升高。结论痔血胶囊所含组分白鲜皮致肝损害的可能性较大,建议临床医师注意辨证施治,避免不良反应的发生。Objective The epidemiological characteristics of acute liver damage induced by Zhixue Capsule was investigated. Methods The severe adverse drug reactions（ADR） reports on liver damage induced by Zhixue Capsule have been analyzed retrospectively. Results 5 patients administered the Zhixue Capsule and the average medication time was（22＋ 12） days. The clinical manifestations of the acute liver damage induced by Zhixue Capsule included jaundice,fatigue,fever,abdominal distension,nausea,anorexia and poor appetite. Liver function examination showed that the alanine aminotransferase（ALT） was between 599～3380 U/L,the total bilirubin（TBIL） was between 5.6～489μmol/L,and the eosinophilic granulocyte also get higher after administration. Conclusion The densefruit pittany root-bark in Zhixue Capasule may be the major cawse of the acute liver damage. So it suggest that clinician should determine the treatment based on differentiation of sym ptoms and signs to Drug-induced liver damage should be evaluated,and promote rational use of drugs,decrease the incidence of adverse drug reactions.

关 键 词：痔血胶囊 肝损害 药品不良反应 

分 类 号：R93[医药卫生—生药学] R994.11[医药卫生—药学]