细辛脑注射液雾化吸入对AECOPD痰中白介素8、肿瘤坏死因子α水平变化的影响  

Effect of pulverization of asarone injection on the quantities of IL-8 and TNF-α in acute exacerbation of chronic obstructive pulmonary disease

作　　者：朱莉莉[1] 杨质秀[2] 李玉梅[1] 梁蕊[1] 张新[1] 李玉[1] 杜继伟[1] 

机构地区：[1]哈尔滨医科大学附属第四医院呼吸内科,150001 [2]黑龙江省中医研究院附属医院呼吸科,哈尔滨150036

出　　处：《国际呼吸杂志》2010年第11期669-671,共3页International Journal of Respiration

基　　金：黑龙江省自然科学基金资助项目（D200658）

摘　　要：目的探讨细辛脑注射液雾化吸入配合常规疗法对慢性阻塞性肺疾病急性加重期（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）痰中白介素8（interleukin-8，IL-8）、肿瘤坏死因子α（tumornecrosis factor alpha，TNF-α）水平变化的影响。方法选择住院的AECOPD患者154例，随机分为常规疗法组和联用细辛脑治疗组；联用细辛脑治疗组在常规疗法的基础上联用细辛脑注射液雾化吸入治疗，用ELISA法分别检测其血清及痰液IL-8及TNF-α的含量。结果常规疗法IL-8含量明显高于联用细辛脑组（3．0812±0．3781VS1．2466±0．6049，P〈0．05）；常规疗法TNF-α含量明显高于联用细辛脑组（O．2055±0．5166VS0．1152±0．0734，P〈0．05）。结论在常规疗法的基础上联用细辛脑注射液雾化吸入治疗时可减少AECOPD痰中IL-8、TNF-α的含量。Objective To observe the quantities of interleukin-8 （IL-8）and tumor necrosis factor alpha（TNF-α）in sputum in patients with pulverization of asarone injection combined with routine methods in acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods 154 patients with AECOPD were divided into two groups randomly. In the combined group, we added pulverization of asarone injection in the treatment. The quantities of IL-8 and TNF-α in sputum were tested by ELISA. Results The quantities of IL-8 of routine methods group increased significantly compared with that of the combined group（3. 081 2±0. 378 1 vs 1. 246 6±0. 604 9, P d0.05）. The quantities of TNF-α of routine methods group increased significantly compared with that of the combined group（0. 205 5±0. 516 6 vs 0. 115 2±0.073 4, P 〈 0.05 ）. Conclusions On the basis of routine treatment, combined with pulverization of asarone injection can remarkably reduced the quantities of IL-8 and TNF-α in AECOPD.

关 键 词：慢性阻塞性肺疾病 细辛脑注射液 雾化吸入白介素8 肿瘤坏死因子Α 

分 类 号：R563.9[医药卫生—呼吸系统]