吉士脱酮的~1H及^(13)CNMR研究  

1H NMR AND 13 C NMR STUDY ON GESTODENE

作　　者：盛宛云[1] 白秀梅[1] 

机构地区：[1]上海市计划生育科学研究所国家计划生育药具实验室

出　　处：《波谱学杂志》1999年第1期65-70,共6页Chinese Journal of Magnetic Resonance

摘　　要：Ｇｅｓｔｏｄｅｎｅ是避孕药物１８甲基炔诺酮的衍生物，动物实验表明它的孕激素活性为１８甲基炔诺酮的３～５倍．本文采用各种２ＤＮＭＲ技术，包括：１Ｈ１ＨＣＯＳＹ，１Ｈ１３ＣＣＯＳＹ和ＨＭＢＣ等，归属了它的１Ｈ和１３Ｃ的谱线。In this article, 1H and 13 C NMR spectra of Gestodene were analyzed by using two dimensional 1H 1H COSY, heteronuclear 1H 13 C shift correlation and HMBC, It was made possible to assign 1H and 13 C NMR spectra of Gestodene completely by combination of these techniques, Gestodene showed complex 1H signal around 1.4-2.6ppm and 13 C signals around 25.3-38.13ppm, This combination of techniques is applicable for assignment of highly overlapping signals, The HMBC spectra can provide valuable information for assignment of 1H and 13 C NMR signals,

关 键 词：口服避孕药 二维核磁共振 谱线归属 吉士脱酮 

分 类 号：R979.21[医药卫生—药品]