轻度血尿伴或蛋白尿患者临床病理特点及尿蛋白危险因素分析  

Pathological characteristics of patients with mild proteinuria and/or hematuria and risk factors associated with urinary protein

作　　者：叶建华[1] 周晓玲[2] 陈孟华[2] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2010年第6期522-523,共2页Ningxia Medical Journal

基　　金：宁夏自治区科技攻关资助项目(05GG-20705)

摘　　要：目的探讨轻度血尿伴(或)蛋白尿患者的肾脏病理特点及影响尿蛋白量的主要因素。方法分析71例轻度血尿伴(或)蛋白尿患者的临床病理特点;依据24小时尿蛋白定量将患者分为两组:A组28例(尿蛋白定量≤1g/24h),B组43例(1g/24h<尿蛋白定量≤1g/24h),观察两组患者的临床特点及对24h尿蛋白量的影响。结果患者病理类型FSGS占3%,IgA肾病占56%,膜性肾病占23%,系膜增生性肾炎占9%,其余占9%。多元逐步回归分析显示,病程及总胆固醇是24h尿蛋白量的危险因素。结论以轻度肾小球性血尿伴(或)蛋白尿为主要表现的患者临床与病理表现的严重程度并不一致,病程和总胆固醇是尿蛋白定量的独立危险因素,对该类患者应行肾穿刺活检病理检查并早期进行临床干预。Objective To observe the pathological characteristics of patients with mild proteinuria and/or hematuria and study the risk factors associated with urinary protein.Method 71 clinical and pathological datum of the patients were collected from the inpatients.The patients were divided into 2 groups according urinary protein excretion：group A 28 cases（UPQ≤1g/24h）,group B 43 cases（1g/24hUPQ≤2g/24h）.The clinical features and risk factors of urinary protein excretion were analyzed.Results The renal pathology types were 3% FSGS,56% IgA nephropathy,23%membranous nephropathy,9%mesangial proliferative glomerulonephritis,9% other types.Multiple stepwise regression analysis showed that clinical course and cholesterol were risk factors for the proteinuria.Conclusion Pathological characteristics in mild proteinuria and/or hematuria are polymorphism;the clinical features do not consist with pathological lesion.The clinical course and cholesterol were risk factors for the proteinuria.

关 键 词：血尿 蛋白尿 肾脏 

分 类 号：R692.31[医药卫生—泌尿科学]