参附强心合剂对心衰大鼠血流动力学的影响  

Effects of Shenfuqiangxin Decoction on influence of Haemodynamics in Chronic Heart Failure Rats

作　　者：祝光礼[1] 陈铁龙[1] 魏丽萍[1] 刘昭[1] 

机构地区：[1]浙江中医药大学附属广兴医院心内科,浙江杭州310007

出　　处：《中华中医药学刊》2010年第6期1125-1127,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市科技局立项课题(LX2007)

摘　　要：目的:探讨参附强心合剂对心衰大鼠血流动力学的影响。方法:采用腹主动脉缩窄法制做心衰大鼠模型,颈动脉插管法通过生物信号采集系统收集各项参数,观察参附强心合剂对心衰大鼠血流动力学的作用。结果:参附强心合剂各剂量组和西药组均能升高LVSP、+dp/dtmax、-dp/dtmax、Vmax,降低LVEDP,心功能的各项指标较模型对照组明显改善(P<0.05)。中药各治疗组与西药对照组比较无明显差异(P>0.05)。结论:参附强心合剂具有改善慢性心衰血流动力学指标及保护心脏的作用。Objective：To investigate the influence of Shenfuqiangxin（SFQX） decoction on haemodynamics in chronic heart failure （CHF） rats. Methods：Using male adult SD rats made CHF models by coarctation of abdominal aorta（CAA）. LVSP ＋dp/dtmax -dp/dtmax Vmax and LVEDP were measured through the tube inserted into the carotid artery and analysed by the MED-labU/4C system software. To observe the change of haemodynamics. Results：The heart function were obvionsly improved in SFQX decoction big、morderate,small dose group,and the western medicine group compared with the model control group：LVSP,＋dp/dtmax,-dp/dtmax,Vmax were increased and the LVEDP was decreased（P0.05）.However there were no difference among 4 drug treated groups. Conclusion：SFQX decoction could significantly improve haemodynamics and protect heart.

关 键 词：参附强心合剂 心力衰竭 血流动力学 

分 类 号：R285.5[医药卫生—中药学]