肝线粒体在NAFLD中的病理变化及中药辨证干预的实验研究  

Empirical Study on Pathological Change and TCM Syndrome Differentiation Intervention of Liver Mitochondria in NAFLD

作　　者：黎运呈[1] 李世波[1] 丁贤君[1] 徐方明[1] 刘华生[1] 曾芳[1] 

机构地区：[1]舟山市人民医院感染科,浙江舟山316004

出　　处：《中华中医药学刊》2010年第6期1285-1287,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨肝线粒体在NAFLD发病过程中的超微病理变化及中医辨证治疗的影响。方法:取SPF级Wistar大鼠40只,随机分为5组。造模并干预给药,于实验第12周时,处死大鼠,取肝组织制作肝脏的超微病理切片,观察各组肝细胞线粒体的病理变化及中药辨证干预的影响。结果:肝细胞线粒体在各造模组中有不同程度的病理改变。在12周时,药物B方保护肝线粒体的疗效较其他干预措施为优。结论:在NAFLD的后期采取化痰消瘀、清热利湿、补益肝肾治法对于保护肝细胞线粒体疗效突出。Objective：Approach on the ultramicro-pathological change and TCM treatment intervention action of liver mitochondria in the development of NAFLD. Methods：Fetched 40 Wistar rats＇ level of SPF,were divided into 5 groups at random. Modeled and medicine intervened,on 12th weeks,executed rats,took the rats＇ liver make pathological section,observed the ultramicro-pathological change and action of TCM syndrome differentiation interfering hepatocytes mitochondrial in each group. Results：The livers mitochondria have made varying degrees of pathological changes in each group. At 12th weeks,Medicine B had better curative effect on protecting the liver mitochondria than other interventions. Conclusion：At the anaphase of NAFLD,adopting the treatment of dissipating phlegm and eliminating blood stasis,clear heat and drain dampness,reinforcing liver benefiting kidney to protect liver mitochondria have outstanding efficacy.

关 键 词：NAFLD 线粒体 辨证干预 

分 类 号：R2-03[医药卫生—中医学]