止咳颗粒治疗慢性支气管炎的动物实验研究  

Treatment of chronic bronchitis with Zhike particles

作　　者：彭素岚[1] 敖素华[1] 王俊峰[1] 肖顺汉[1] 陈方姗[1] 

机构地区：[1]泸州医学院附属中医医院呼吸科,四川泸州646000

出　　处：《西部医学》2010年第6期998-1000,共3页Medical Journal of West China

摘　　要：目的探讨研究止咳颗粒对实验大鼠的镇咳、祛痰、平喘及抗炎作用。方法通过对实验大鼠气管内注入脂多糖法建立大鼠慢性支气管炎模型,采用氨水引咳法观察止咳颗粒的镇咳作用;大鼠气管酚红排泄法观察止咳颗粒的祛痰作用;组织胺致大鼠喘息法观察止咳颗粒的平喘作用;蛋清致大鼠足肿胀实验、大鼠琼脂肉芽肿实验观察止咳颗粒的抗炎作用;运用摄影生物学显微镜观察肺组织的病理学改变。结果止咳颗粒能减少大鼠咳嗽的次数,与对照组比较有显著性差异(P<0.05或P<0.01);止咳颗粒能增加大鼠气道酚红排泄量,与对照组比较具有显著性差异(P<0.05或P<0.01);止咳颗粒能减轻蛋清所致的大鼠足跖肿胀程度,与对照组比较具有显著性差异(P<0.05或P<0.01);止咳颗粒能明显延长组织胺所致大鼠喘息的潜伏期,与对照组比较有显著性差异(P或P<0.01)。病理组织学检查发现:止咳颗粒能不同程度减轻慢性支气管炎大鼠支气管粘膜层和粘膜下层炎性细胞的浸润、减轻粘膜上皮细胞的坏死和脱落,减少气道分泌物。结论止咳颗粒对慢性支气管炎有较好的止咳、祛痰、平喘及抗炎治疗效果。Objective To study Zhike particles antitussive,expectorant and anti-asthma effects in animals.Methods The rat model of chronic bronchitis was induced with intratracheal instillation of lipopolysaccharide.The effects of Zhike particles were observed.Results Zhike particles can reduce the frequency of cough group,increase the airway excretion of phenol red,reduce the egg white-induced rat paw edema extent,prolong the incubation period of breathing in guinea pigs induced by histamine,compared with control group（P〈0.01）.The histopathological examination revealed Zhike particles could reduce the chronic bronchitis rats with varying degrees of bronchial mucosa and submucosa infiltration of inflammatory cells,and reduce airway secretions.Conclusion Zhike particles have a better therapeutic effect on curing chronic bronchitis.

关 键 词：止咳颗粒 动物实验 慢性支气管炎 

分 类 号：R285.5[医药卫生—中药学] R562.21[医药卫生—中医学]