瘿消颗粒剂的药效学研究  

Studies on the Pharmacodynamics of Ying Xiao Granule

作　　者：张才丽[1] 王宏镛[1] 张京玲[1] 李冬生 孙贵连 

机构地区：[1]天津医科大学药理学教研室,300070

出　　处：《中草药》1999年第3期199-201,共3页Chinese Traditional and Herbal Drugs

摘　　要：正常小鼠ｐｏ瘿消颗粒剂 ２０ ｄ后，使小鼠机体耗氧量明显低于正常对照组，效果与他巴唑相同。瘿消颗粒剂对实验性甲状腺机能亢进家兔的体重、体温、心率、心电图、血清Ｔ_(３)、Ｔ_(４)值等各项指标均有明显改善，并使甲状腺的功能和形态基本恢复正常。它还可使正常大鼠血清Ｔ_(４)值下降，其作用与他巴唑相似，说明该方剂有明显的抗甲状腺机能亢进作用。Oral administration of Ying Xiao granule (YXG) to normal mice for 20 days, resulted in a pronounced decrease of oxygen consumption as compared with that of the normal controls. The effect was almost same as Thiamazole. YXG prominently improved the body weight, body temperature, heart rate, EKG, and serum T_(3), T_(4) values of experimental hyperthyroidism rabbits, and basically recovered their thyroid functions and morphology. This preparation also decreased serum T_(4) of euthyroid rats with a similar effect as Thiamazole. These restults showed that YXG has strong antithyroid effects.

关 键 词：瘿消颗粒剂 甲状腺机能亢进 药效学 

分 类 号：R285.5[医药卫生—中药学] R259.811[医药卫生—中医学]