强化阿托伐他汀治疗急性冠脉综合征患者临床随访观察  

Study of curative effect of acute coronary syndrome by intensive atorvastatin therapy

作　　者：张小玲[1] 叶青[1] 周俊岭[1] 严激[1] 

机构地区：[1]安徽省立医院心血管内科,合肥230022

出　　处：《安徽医学》2010年第5期496-497,共2页Anhui Medical Journal

摘　　要：目的探讨强化阿托伐他汀治疗急性冠脉综合征(ACS)的临床疗效,观察超敏C-反应蛋白(Us-CRP)及血脂水平的变化。方法选择65例急性冠脉综合征患者于治疗前,及治疗后4周、12周、24周检测Us-CRP和血脂水平,对比分析,并与健康对照组34例Us-CRP进行对比。结果 ACS患者治疗后4周、12周、24周后Us-CRP、总胆固醇、低密度胆固醇、三酰甘油均明显降低(P(0.01),高密度胆固醇有明显升高(P(0.01)。结论坚持强化阿托伐他汀治疗ACS能提高患者降脂治疗达标率,且持续降低患者血清超敏C反应蛋白,抑制斑块内炎症反应。Objective To probe into curative effect of acute coronary syndrome （ACS） by Intensive atorvastatin therapy, and to be observed the change Ultrasensitive C - reactive protein（ Us - CRP） and Lipids Levels. Methods 65 ACS patients were assessed by detecting Us- CRP and lipids levels at before therapy, and after therapy 4th week, 12th week and 24th week, and also compared Us -CRP with 34 healthy persons. Results Us - CRP, The total cholesterol, low density lipoprotein cholesterol, and triglyceride of ACS patients are all reduced（P 〈 0.01 ）after therapy 4 weeks, 12 week and 24 weeks, high density lipoprotein cholesterol is increased（P 〈 0.01 ）. Conclusion To persevere in intensive atorvastatin therapy increased the rate of reaching the Lipoprotein regulating goal of ACS patients, and continually reduced Us -CRP, and control plaque inflammation.

关 键 词：阿托伐他汀 急性冠脉综合征 超敏C-反应蛋白 血脂 

分 类 号：R541.4[医药卫生—心血管疾病]