烟酸糖酯的合成、晶体结构及生物活性  

Synthesis,crystal structure and bioactivity of glucosyl esters of nicotinic acid

作　　者：李一鸣[1] 李玉新[1] 王浩安[1] 徐俊英[1] 王素华[1] 李正名[1] 

机构地区：[1]南开大学元素有机化学研究所,元素有机化学国家重点实验室,天津300071

出　　处：《化学试剂》2010年第6期481-483,共3页Chemical Reagents

基　　金：天津自然科学基金资助项目(09JCZDJC21300)

摘　　要：采用相转移催化法,合成了β型取代全乙酰糖酯,其结构经1HNMR、元素分析、质谱证实。单晶结构解析表明,目标化合物的构型为β型,溴代乙酰葡萄糖只能接受β方向的亲核进攻,从而立体选择性地合成了β型糖苷。化合物初步生测结果表明该类新化合物具有一定杀菌活性。To discover novel bioactive organic compounds,a series of saccharide carboxylates of nicotinic acid were stereo-selectively synthesized via the phase transfer catalytic method.Their structures were characterized by 1HNMR,elemental analysis and MS.Furthermore,the X-ray diffraction measurement revealed that the configuration of the target compounds was β type.The bioassay results indicated that some of these compounds displayed moderate fungicidal and herbicidal activity.

关 键 词：烟酸糖酯 杀菌活性 晶体结构 

分 类 号：S482.2[农业科学—农药学]