N-(2-吡咯甲酰基)-β-丙氨酸甲酯的烷基化反应  

Alkylation of methyl 3-(1H-pyrrole-2-carbonyl)aminopropanoate

作　　者：黎冬冬[1] 徐兴烟[1] 柳翔[1] 曾向潮[1] 唐桂红[1] 

机构地区：[1]暨南大学化学系,广东广州510632

出　　处：《化学试剂》2010年第6期493-495,528,共4页Chemical Reagents

基　　金：广东省自然科学基金资助项目(06300581)

摘　　要：以四丁基溴化铵为相转移催化剂,乙腈为溶剂,无水碳酸钾作用下,氯苄等卤代烃与N-(2-吡咯甲酰基)-β-丙氨酸甲酯反应,合成了系列N-(1-烷基-2-吡咯甲酰基)-β-丙氨酸酯,通过1HNMR、IR对其进行结构表征。A series of 3-（1-alkylpyrrole-2-carbonyl）aminopropionic acid esters were synthesized by alkylation of methyl 3-（1H-pyrrole-2-carbonyl）aminopropanoate using halohydrocarbons,like benzylchloride,as the alkylating agents,in the presence of anhydrous K2CO3 and TBAB in acetonitrile under refluxing.Structures of the products were characterized by 1HNMR and IR.

关 键 词：N-(1-烷基-2-吡咯甲酰基)-β-丙氨酸酯 合成 烷基化 

分 类 号：O625.8[理学—有机化学]