荷移分光光度法测定阿替洛尔  

Spectrophotometric determination of atenolol based on charge transfer reaction

作　　者：刘佳川[1] 李华侃[1] 陈连山[1] 赵延清[1] 

机构地区：[1]辽宁医学院化学教研室,辽宁锦州121001

出　　处：《化学试剂》2010年第6期526-528,共3页Chemical Reagents

摘　　要：采用分光光度法研究了阿替洛尔与茜素红之间的荷移反应。确定了最佳的反应条件,建立了一种快速简便测定阿替洛尔的荷移分光光度法。实验表明,在乙醇-水介质中,阿替洛尔与茜素红在室温条件下即可形成稳定的1∶1型荷移配合物,该配合物的λm ax=536 nm,表观摩尔吸光系数ε为4.58×10^3L·mol^-1·cm^-1。阿替洛尔药物质量浓度在10-60 mg/L范围内服从比尔定律,相关系数r为0.999 3。测定结果的相对标准偏差为0.57%（n=6）,回收率为99.3%-101.8%。The charge-transfer reaction of atenolol and alizarin red was investigated by spectrophotometry.The optimum experimental conditions were established,and a simple and rapid method for determination of atenolol had been developed.Results showed that the ratio of atenolol and alizarin red in the composition of charge transfer complex was 1∶1 in ethanol-water solution at room temperature.The apparent molar absorptivity of the complex was 4.58×10^3 L·mol^-1·cm^-1 at 536 nm.The Beer′s Law was obeyed in the range of 10～60 mg/L of atenolol with a correlation coefficient of 0.999 3.The relative standard deviation was 0.57%（n=6）.The recovery was 99.3%～101.8%.

关 键 词：荷移反应 分光光度法 阿替洛尔 茜素红 

分 类 号：O657.32[理学—分析化学]