聚α-羟基辛酸对W/O乳液电纺聚乳酸纤维毡中阿霉素释放的影响  

Effect of Poly(α-hydroxyoctanioc acid) Addition on Doxorubicin HCl Release from W/O Emulsion Electrospun Poly(L-lactic acid) Fibrofelts

作　　者：王浩[1] 宋宏锐[2] 邓英杰[1] 陈学思[3] 

机构地区：[1]沈阳药科大学药学院 [2]沈阳药科大学制药工程学院,辽宁沈阳110016 [3]中国科学院长春应用化学研究所高分子化学与物理国家重点实验室,吉林长春130022

出　　处：《合成化学》2010年第3期273-279,共7页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(50373043);中国科学院科技创新基金资助项目(KJCX2-SW-H07)

摘　　要：采用内酯开环聚合法合成了聚乙二醇-b-聚(L-乳酸)(1)和聚乙二醇-b-聚(α-羟基辛酸)(2),将1和2一起溶解在二氯甲烷中为油相,以盐酸阿霉素(3)水溶液为内水相,用超声分散法形成油包水(W/O)乳液后静电纺丝,形成外壳为[1+2],内芯包裹有3的纤维毡。扫描电子显微镜和广角X-射线扫描分析未发现纤维表面析出3结晶。纤维毡的酶降解药物释放研究结果表明,2的添加不仅未明显改变3的释放行为,而且可改善纤维对酶降解的耐受性。3的释放行为经Weibull模型和Highchi模型拟合,回归系数较高。Polyethylene glycol-b-poly（L-lactic acid）（1）and polyethylene glycol-b-poly（α-hydroxy-octanoic acid）（2）was synthesized by ring opening polymerization.1 and 2 was mixed in CH2Cl2 forming oil phase and ultra-sonicated with doxorubicin HCl water solution to form water in oil（W/O）emulsion.The W/O emulsion was immediately electrospun to form fibrofelts with hybrid polymer shell and drug core structure.By scanning electronic microscope observation and wide angle X-ray diffraction detection,drug crystal was not found on the fibers.Drug release experiment under enzyme degradartion indicated that addition of 2 did not change the release behavior of fibers and made the fibers resisted to enzyme degradation.Drug release behavior obeyed Weibull model and Highchi model after regression.

关 键 词：聚乳酸 聚α-羟基辛酸 W/O乳液 静电纺丝 药物释放 

分 类 号：O632.3[理学—高分子化学]