阻塞性睡眠呼吸暂停低通气综合征与糖代谢改变及机制探讨  

Obstructive Sleep Apnea Hypopnea Syndrome and Disorders of Glucose Metabolism

作　　者：孟炜丽[1,2] 连赫宇 郭兮恒[1] 

机构地区：[1]首都医科大学附属北京朝阳医院睡眠中心,北京100020 [2]首都医科大学 [3]北京航天科工集团731医院,北京100074

出　　处：《中国现代医生》2010年第17期5-8,共4页China Modern Doctor

摘　　要：阻塞性睡眠呼吸暂停低通气综合征是一常见病,众多研究表明糖尿病的发生、发展与阻塞性睡眠呼吸暂停低通气综合征密切相关,阻塞性睡眠呼吸事件可导致许多急性的病理生理改变如间断低氧、严重睡眠片段、交感神经系统激活、激素和炎症因子的分泌紊乱、脂肪组织内分泌功能紊乱等,反复而长期的上述改变最终可导致糖代谢异常。Obstructive sleep apnea hypopnea syndrome（OSAHS） is a prevalent disorder in middle-aged obese men. The recurrent obstructive respiratory event during sleep can cause many acute pathophysiological changes such as intermittent hypoxemia, fragmented sleep, sympathetic nerve activation, abnormal secretion of hormone and inflammation factors and endocrinic disfunction in human adipose tissue,which can finally cause disorders of glucose metabolism.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 糖代谢异常 持续正压通气治疗 

分 类 号：R56[医药卫生—呼吸系统]