子痫前期患者血浆抑制素A、纤溶相关因子水平变化的意义  

Levels of Plasma Inhibin A and Fibrinolytic Factors in Preeclampsia Pregnant Women

作　　者：钱金花[1] 徐美龄[1] 邵翠华[1] 

机构地区：[1]青岛大学医学院附属医院产科,山东青岛266033

出　　处：《中国现代医生》2010年第17期18-19,共2页China Modern Doctor

摘　　要：目的探讨子痫前期患者血清中抑制素A(INH-A)、纤溶相关因子(t-PA、PAI-1、PAI-2)水平变化及临床意义。方法对34例子痫前期孕妇及50例正常妊娠孕妇应用酶联免疫吸附试验(ELISA)测定妊娠24～28周和28～34周两时段中外周血t-PA、PAI-1和PAI-2及胎盘分泌抑制素A浓度,并进行对比分析。结果子痫前期组INH-A、t-PA、PAI-1水平均高于正常妊娠组(P<0.01),而PAI-2水平孕晚期显著低于正常妊娠组(P<0.05);抑制素A与t-PA、PAI-1水平呈正相关(r=0.28,P<0.01,r=0.37,P<0.01);孕中期抑制素A与PAI-2无相关关系,但孕晚期二者呈负相关关系(r=-0.31,P<0.05)。结论 t-PA、PAI-1、INH-A的高表达在子痫前期的发病中起重要作用,可作为早期监测子痫前期发生的敏感指标。Objective To investigate the changes and clinical significance of inhibin A and levels of fibrinolytic factors t-PA,PAI-1 and PA I - 2 in preeclampsia pregnant women. Methods Blood samples were collected at 24-28 and 30-36 gestational weeks（GW） in 50 normal pregnant women and 34 preeclampsia pregnant women and the inhibin A,t-PA,PAI-1 and PAI-2 were determined by using enzyme-linked immunosorbent assays. Results The inhibin A PAI-1, PAI-2 and t-PA levels were significantly higher（P〈0.01）and the PAI-2 level was lower（P〈0.05） in the preeclampsia group than those in the normal pregnant group. The inhibin A was positively correlated with t-PA and PAl- 1 （r=0.28, P=0.01 ; t=0.37, P〈0.01 ）after the 24 GW, but inversely correlated with PAI-2 after 30GW（r=0.31, P〈0.05 ）. Conclusion The higher expression of t-PA,PAI-1 and inhibin A may play an important role in the pathogenesis of preeelampsia and may help the early diagnosis of preeelampsia.

关 键 词：抑制素A T-PA PAI-1 PAI-2 子痫前期 

分 类 号：R714.245[医药卫生—妇产科学]