沙河镇正常高值血压女性人群高血压发病影响因素  

Impact factors of hypertension accession in woman group with high-normal blood pressure in Shahe Town

作　　者：王晓兰[1,2] 魏葳 李国杰[2] 白真真[2] 闫坤丽[2] 张荣立[2] 张红叶[2] 张亮清 

机构地区：[1]长治市人民医院干部病房,046000 [2]北京高血压联盟研究所 [3]北京市昌平区沙河社区卫生服务中心 [4]山西省心血管病医院心内科

出　　处：《中国循证心血管医学杂志》2010年第2期79-82,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨影响血压正常高值(120～139/80～89mmHg)中青年女性人群转归为高血压的主要因素。方法采用前瞻性队列随访研究。2006年3月～4月,对北京市沙河镇血压正常高值中青年女性775人进行了基线调查,2009年9月～10月进行复查,了解新发高血压情况,分析基线特征与该人群新发高血压的关系。结果①本研究人群基线平均血压为(126.8±6.7/80.2±5.6)mmHg,3.5年后复查平均血压为(128.2±13.9/79.2±8.8)mmHg。高血压发病率23.5%(182/775)。②偏相关分析控制年龄后,基线血压值、腰围、体质指数(BMI)、总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)值及胰岛素抵抗指数的自然对数(LnHomaIR)均与随访血压值相关(P<0.05)。③单因素分析表明:高血压发病率与基线年龄、血压水平、腰围及TC/HDL-C值显著正相关(P<0.05)。④logistic回归分析结果显示:基线血压值(收缩压、舒张压)、年龄和腰围增加新发高血压的危险,OR值及95%CI分别为1.050(1.021～1.080)、1.051(1.016～1.087)、1.041(1.010～1.073)和1.036(1.011～1.061)。结论北京市沙河镇地区血压正常高值女性高血压的发病率较高,年龄,基线血压水平及腰围是影响中青年女性血压正常高值人群转归为高血压的重要危险因素。Objective To investigate the main impact factors of hypertension accession in young and middleaged women with high-normal blood pressure （ BP,120 - 139/80 - 89 mm Hg）. Methods The prospective cohort follow-up was applied in the study and the baseline survey was carried out in 775 young and middle-aged women with high-normal BP in Shahe Town of Beijing from March to April,2006. The re-survey was carried out from Sept. to Oct. 2009 in the same woman group to get to know the status of hypertension accession and to analyse the relation between baseline characteristics and hypertension accession. Results （1）The average baseline BP in this group was （ 126.8 ± 6.7/80.2 ±5.6） mm Hg,and （128.2 ±13.9/79.2 ±8.8） mm Hg in the re-survey （after 3.5 years）. The incidence of hypertension was 23.5% （182/775）. （2）After controlling age with partial correlation analysis, baseline BP, waist circumference （WC） ,body mass index （BMI）, ratio of total cholesterol to high-density lipoprotein-cholesterol （TC/ HDL-D） and the natural logarithm of insulin resistance index （Ln Homa IR） were all correlated to follow up BP values （ P 〈 0.05 ）. （3）The result of single factor analysis showed that the incidence of hypertension was correlated significantly to baseline age, BP level, WC and TC/HDL-D （P 〈 0.05 ）. （4）The result of Logistic regression analysis showed that baseline BP values （ systolic pressure and diastolic pressure） ,age and WC increased the risk of hypertension accession, and OR values were, respectively, 1. 050 （95 % CI, 1. 021 - 1. 080 ）, 1.051 （ 95 % CI, 1.016 - 1. 087 ） , 1. 041 （ 95 % CI, 1. 010 - 1. 073） and 1. 036 （95% CI, 1.011 - 1. 061 ）. Conclusion The incidence of hypertension was higher in women with high-normal BP in Shahe Town of Beijing. Age,baseline BP level and WC are the important risk factors of hypertension accession in young and middle-aged women with high-normal BP.

关 键 词：中青年女性 血压正常高值 高血压 发病率 影响因素 

分 类 号：R544.1[医药卫生—心血管疾病]