氟哌啶醇对大鼠海马CA1区γ-氨基丁酸能抑制效应的影响  

Effects of haloperidol on GABAergic inhibition in rat CA1 hippocampal slice.

作　　者：许崇涛 刘协和[1,2,3] 吴前 柴慧霞[1,2,3] 

机构地区：[1]汕头大学精神卫生中心 [2]华西医科大学附一院精神科 [3]华西医科大学生理学教研室

出　　处：《中国神经精神疾病杂志》1999年第2期68-70,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的探讨抗精神病药对海马γ－氨基丁酸（ＧＡＢＡ）能抑制效应的作用。方法利用离体海马脑片技术，采用逆－顺向双脉冲和顺向双脉冲的刺激模式，观察氟哌啶醇（２０μｍｏｌ／Ｌ）、舒必利（１００μｍｏｌ／Ｌ）对共计３１例大鼠海马脑片ＣＡ１区ＧＡＢＡ能抑制效应的影响。结果氟哌啶醇、舒必利对锥体细胞群体峰电位无影响。氟哌啶醇增强逆－顺向双脉冲刺激诱发的双脉冲抑制，减弱顺向双脉冲刺激诱发的双脉冲易化，舒必利无此作用。结论氟哌啶醇增强海马ＣＡ１区ＧＡＢＡ能抑制效应。Objective To probe the effects of neuroleptics on the GABAergic inhibition in hippocampus. Methods By antidromic-orthodromic paired pulse and orthodromic paired pulse stimulation,the effects of haloperidol (20 μmol/L)or sulpiride(100 μmol/L)on the GABAergic inhibition in CA1 region were studied in rat hippocampal slice( n =31). Results Neither haloperidol nor sulpiride had any effect on the population spike.It was haloperidol,not sulpiride that enhanced the paired-pulse inhibition elicited by antidromic-or thodromic paired-pulse stimulation,and reduced the paired-pulse facilitation evoked by orthodromic paired-pulse stimulaion. Conclusions Haloperidol enhanced the GABAergic inhibition in CA1 hippocampus,which was not associated with its blockade of dopamine D 2 receptor.

关 键 词：氟哌啶醇 氨基丁酸能抑制 精神分裂症 海马 

分 类 号：R971[医药卫生—药品] R749.3[医药卫生—药学]