P53、C-erbB-2和VEGF在胃癌中的表达及其临床意义  

Expression of P53,C-erbB-2 and VEGF in gastric cancer and the clinical significance

作　　者：张志强[1] 姜林[2] 李斌[1] 盛黎黎[1] 

机构地区：[1]武警湖北总队医院病理科,湖北武汉430061 [2]武警湖北总队医院消化内科,湖北武汉430061

出　　处：《武警医学院学报》2010年第7期513-515,F0004,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】分析P53、C-erbB-2、VEGF在胃癌组织中的表达与胃癌临床病理特征之间的关系。【方法】收集我院2006年1月-2007年12月经手术切除且病理证实的胃癌病例,记录各患者分化程度、浸润程度、淋巴结转移情况及TNM分期。获得临床资料完整的病例60例,复习病理大体及镜下特点,行免疫组化染色,观察P53、C-erbB-2、VEGF在胃癌组织中的表达情况。【结果】(1)P53基因蛋白在胃癌组织中表达阳性率为60%,P53基因蛋白阳性表达与分化程度、有无淋巴结转移有关。(2)C-erbB-2基因蛋白在胃癌组织中表达阳性率为73.3%。C-erbB-2基因蛋白阳性表达与与浸润程度及淋巴结是否转移有关)。(3)VEGF在胃癌组织中表达阳性率为75%。VEGF阳性表达与浸润深度、淋巴结是否转移及临床分期有关。【结论】联合检测P53、C-erbB-2及VEGF在胃癌组织中的表达对胃癌的临床诊断、病情评估、治疗及预后可提供一定指导。[Objective] By analyzing the relationship between P53, C-erbB-2 and VEGF expression in gastric cancer and clinical features of gastric cancer,to help accurate determination the patient＇s condition and prognosis. [Methods] By collecting surgically reseeted and pathologically confirmed cases of gastric cancer,get 60 cases of complete clinical data. To observe P53, C-erbB-2 and VEGF expression in gastric cancer, and to analyse by using SPSS 10.0 statistical software. [Results] Positive rate of P53 gene expression in gastric cancer was 60%. P53 gene expression was positively correlated with the differentiation and lymphaden metastases. Positive rate of C-erbB-2 gene expression in gastric cancer was 73.3 %. C-erbB-2 gene expression was positively correlated with the extension and lymphaden metastases. Positive rate of VEGF expression in gastric cancer was 75 % .VEGF expression was positively correlated with the extension, lymphaden metastases and clinical stages. [Conclusion] Combined detection of the expression of P53, C-erbB-2 and VEGF in gastric cancer may give some guideline for the clinical diagnosis ,illness evaluation ,treatment and prognosis of gastric cancer.

关 键 词：胃癌 P53蛋白 C—erbB-2蛋白 血管内皮生长因子 

分 类 号：R735.2[医药卫生—肿瘤]